Doris H. Clouet

TL;DR: In tolerant rats, the rate of incorporation of carbon-14 into dopamine and into norepinephrine in these areas is more than twice that in animals that have received only one injection of morphine.

TL;DR: Results from experiments in vitro and in vivo suggest that, while haloperidol has a direct effect on the dopamine receptor-associated cyclase activity, morphine must act by another mechanism, and that chronic use of either drug produces enhanced dopamine sensitivity.

TL;DR: There is no conclusive evidence that the reappearance of esteratic activity after inhibition should be considered protein synthesis, but a study of the sequence of inhibition and recovery of the cholinesterases offers information which may form the basis for an understanding of the origin of these enzyme activities in the central nervous system and peripheral nerve.

TL;DR: The administration of the narcotic antagonist, nalorphine, concurrently with morphine did partially reverse the effects found after morphine alone, and the effects of morphine treatment on the [14C]leucine pool and on the rate of protein turnover were not significantly altered.

TL;DR: The inhibition of protein synthesis caused by acute administration of morphine was calculated to be greater than previously reported since morphine treatment increased the specific radioactivity of the free pool of leucine in brain following the intracisternal injection of the labelled amino acid.