D
Dorothea K. Thompson
Researcher at Campbell University
Publications - 61
Citations - 3745
Dorothea K. Thompson is an academic researcher from Campbell University. The author has contributed to research in topics: Shewanella oneidensis & Gene. The author has an hindex of 29, co-authored 59 publications receiving 3557 citations. Previous affiliations of Dorothea K. Thompson include Center for Biologics Evaluation and Research & University of Tennessee.
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Journal ArticleDOI
Development and Evaluation of Functional Gene Arrays for Detection of Selected Genes in the Environment
Liyou Wu,Liyou Wu,Dorothea K. Thompson,Guangshan Li,Richard A. Hurt,James M. Tiedje,Jizhong Zhou,Jizhong Zhou +7 more
TL;DR: The results indicate that glass-based microarray hybridization has potential as a tool for revealing functional gene composition in natural microbial communities; however, more work is needed to improve sensitivity and quantitation and to understand the associated issue of specificity.
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Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation
Yongqing Liu,Jizhong Zhou,Marina V. Omelchenko,Alexander S. Beliaev,Amudhan Venkateswaran,Julia Stair,Liyou Wu,Dorothea K. Thompson,Dong Xu,Igor B. Rogozin,Elena K. Gaidamakova,Min Zhai,Kira S. Makarova,Eugene V. Koonin,Michael J. Daly +14 more
TL;DR: Microarray data suggest that DEIRA cells efficiently coordinate their recovery by a complex network, within which both DNA repair and metabolic functions play critical roles, including a predicted distinct ATP-dependent DNA ligase and metabolic pathway switching that could prevent additional genomic damage elicited by metabolism-induced free radicals.
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Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory
Feng Luo,Feng Luo,Yunfeng Yang,Jianxin Zhong,Jianxin Zhong,Haichun Gao,Haichun Gao,Latifur Khan,Dorothea K. Thompson,Dorothea K. Thompson,Jizhong Zhou,Jizhong Zhou +11 more
TL;DR: The authors' rigorous analysis of gene expression microarray profiles using RMT has showed that the transition of NNSD of correlation matrix of microarray profile provides a profound theoretical criterion to determine the correlation threshold for identifying gene co-expression networks.
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Challenges in applying microarrays to environmental studies.
TL;DR: Adapting microarray hybridization for use in environmental studies faces several challenges associated with specificity, sensitivity and quantitation.
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Global Transcriptome Analysis of the Heat Shock Response of Shewanella oneidensis
Haichun Gao,Yue Wang,Xueduan Liu,Tingfen Yan,Liyou Wu,Eric J. Alm,Adam P. Arkin,Dorothea K. Thompson,Jizhong Zhou +8 more
TL;DR: The majority of the genes that showed homology to known chaperones and heat shock proteins in other organisms were highly induced, and a putative regulatory site with high conservation to the Escherichia coli sigma32-binding consensus sequence was identified upstream of a number of heat-inducible genes.