D
Douglas J. Christie
Researcher at University of Minnesota
Publications - 28
Citations - 831
Douglas J. Christie is an academic researcher from University of Minnesota. The author has contributed to research in topics: Platelet & Antibody. The author has an hindex of 17, co-authored 28 publications receiving 826 citations. Previous affiliations of Douglas J. Christie include Medical College of Wisconsin & University of Wisconsin–Milwaukee.
Papers
More filters
Journal ArticleDOI
Fab-mediated binding of drug-dependent antibodies to platelets in quinidine- and quinine-induced thrombocytopenia.
TL;DR: Findings suggest that binding of drug-induced antibodies to platelets occurs at the Fab domains of the IgG molecule.
Journal ArticleDOI
Characterization of multiple quinine-dependent antibodies in a patient with episodic hemolytic uremic syndrome and immune agranulocytosis
David F. Stroncek,Gregory M. Vercellotti,Dale E. Hammerschmidt,Douglas J. Christie,Raji A. Shankar,Harry S. Jacob +5 more
TL;DR: A 23-year-old woman experienced six distinct episodes of severe combined neutropenia and thrombocytopenia, lymphopenia, and anemia that were due to quinine-dependent antibodies, and that these antibodies recognized epitopes that were different in the three target cell populations.
Journal ArticleDOI
Drug-Antibody-Platelet Interaction in Quinine- and Quinidine-induced Thrombocytopenia
TL;DR: It is demonstrated that in quinine- and quinidine-induced thrombocytopenia, drug and antibody combine first in the soluble phase to form a complex, which then binds with high affinity to a receptor on the platelet surface (innocent bystander reaction), and that these antibodies are heterogeneous in respect to the amount of drug required to promote their binding to platelets, the number of platelet receptors they recognize, and their binding affinities.
Journal ArticleDOI
Vancomycin-dependent antibodies associated with thrombocytopenia and refractoriness to platelet transfusion in patients with leukemia.
TL;DR: These findings provide the first major evidence for drug-dependent antibodies in association with severe thrombocytopenia and refractoriness to platelet transfusion in alloimmunized leukemia patients and, further, provides the first demonstration of vancomycin- dependent antibodies reactive with platelets.
Journal ArticleDOI
Posttransfusion purpura due to an alloantibody reactive with glycoprotein Ia/IIa (anti-HPA-5b)
TL;DR: Findings demonstrate that posttransfusion purpura may be induced by antibodies directed against an alloantigenic epitope, namely HPA-5b (Bra), located on GPIa/IIa, and that clinically significant bleeding can be associated with antibody reactions directed against this GP complex.