Showing papers in "Blood in 1991"

TL;DR: The recent cloning of a naturally occurring IL-1 receptor antagonist (IL-1ra) has opened new experimental and clinical approaches and reduced the severity of diseases such as hemodynamic shock, lethal sepsis, inflammatory bowel disease, experimental arthritis, and the spontaneous proliferation of human leukemic cells.

TL;DR: It is concluded that antibody STRO-1 binds to BM stromal elements with the capacity to transfer the hematopoietic microenvironment in vitro.

TL;DR: Direct evidence is provided for the existence of a single class of progenitors with extensive proliferative capacity in human BM and an experimental approach for their purification, manipulation, and further characterization is provided.

TL;DR: In vitro and in vivo studies suggest that all-trans retinoic acid (RA) treatment restores cell maturation, and the first permanent cell line with t(15;17), derived from the marrow of a patient with APL in relapse is isolated.

TL;DR: The immune recognition-induced lymphokines (ILs) as discussed by the authors are a class of proteins that are specifically designed for peptides derived from the eliciting antigen, bound to a groove in a class I or a class II major histocompatibility complex molecule.

TL;DR: Among recipients of T-cell-depleted transplants for early leukemia, radiation doses greater than or equal to 11 Gy, dose rates greater than 14 cGy/min, and additional posttransplant immune suppression with cyclosporine alone or methotrexate were associated with fewer treatment failures but use of monoclonal antibodies rather than physical techniques for T- cell depletion and fractionated radiation was associated with increased treatment failure and lower leukemia-free survival.

TL;DR: It is demonstrated that restoration of CMV-specific CTL responses may require an extended time period after BMT in some patients, and that such patients are at increased risk of developing severe CMV disease.

TL;DR: Reduction of infarct size, preservation of ventricular function, and reduction in mortality has been obtained with SK, rt-PA, and APSAC, and thrombolytic therapy has become standard treatment for early acute myocardial infarction.

TL;DR: The data presented in this article favor clinical use of the CD34/CD33 flow cytometry assay to guide harvesting of circulating hematopoietic progenitors for autologous transplantation and contribute to better understanding of the role played by circulating hepatopoiety progenitor cell subsets in marrow recovery after myeloablative cancer therapy.

TL;DR: Three studies suggest that CD34+ marrow cells are capable of reconstituting hematopoiesis in humans, and five patients showed durable engraftment until the time of death 82 to 386 days posttransplant.

TL;DR: Findings indicate that LEC-CAM 1 mediates the adhesive interaction underlying leukocyte rolling and thus may play an important role in inflammation and in pathologic conditions involving leukocytes.

TL;DR: This first anti-IL-6 clinical trial demonstrated the feasibility of injecting anti-interleukin-6 MoAbs, and also a transient tumor cytostasis and a reduction in IL-6-related toxicities.

TL;DR: A large panel of monoclonal antibodies was used to characterize in detail the phenotypic changes during isolation and stimulation of human neutrophils and concluded that 7D5-as "early activation" marker--does not necessarily discriminate between primed or resting neutrophil with respect to NADPH oxidation activity.

TL;DR: Clinical and laboratory findings are compatible with reported in vitro and in vivo effects of several inflammatory cytokines and indicate that studies of FHL may contribute to the understanding of cytokine effects in vivo.

TL;DR: The clinical course was progressive with a median survival of 7.5 months and the response rate increased to 58% in patients with a CD4+ CD8- phenotype, and a subgroup of patients may benefit from deoxycoformycin.

TL;DR: It is suggested that RA should be replaced by conventional chemotherapy as soon as CR is achieved, and the sensitivity of newly emerged leukemic clones to RA was greatly reduced.

TL;DR: It is suggested that mdr1 expression contributes to chemoresistance in acute leukemia, and determination of m dr1 gene expression may be useful in designing therapy for patients with leukemia.

TL;DR: It is concluded that IDR/Ara-C can effectively replace standard therapy with DNR/ARA-C in adult patients less than age 60 with newly diagnosed AML.

TL;DR: Pure recombinant human MCP-1/JE is purified and demonstrated that it is chemotactic for human monocytes with a specific activity similar to natural M CP-1 and helps to define functionally a well-known growth factor-inducible gene and a member of a new family of cytokines.

TL;DR: In this article, the authors used the polymerase chain reaction and primers for the V and J regions of the Ig heavy chain gene or T-cell receptor gamma-chain gene to detect gene rearrangement.

TL;DR: In this article, gene rearrangement and monoclonality have been detected in normal cells and in lymphoproliferative disease by using the polymerase chain reaction and primers for the V and J regions of the Ig heavy chain gene or T-cell receptor gamma-chain gene.

TL;DR: PCR was positive in all patients after treatment although the BM was histologically uninvolved in 50% of cases, showing that conventional therapy did not eradicate bcl-2-positive cells.

TL;DR: Allogeneic BMT appears to induce a clinically significant graft-versus- lymphoma effect, similar to that reported against leukemias.

TL;DR: It is shown that the Rh locus carried by the genome of RhD-positive individuals is composed of two different but strongly related genes of identical general organization whether they expressed the C or c and E or e antigens, and, surprisingly, even when they do not express these epitopes.

TL;DR: The potent synergistic interaction between SCF and other hematopoietic growth factors on a highly immature population of CD34+lin- precursor cells is demonstrated.

TL;DR: The hypothesis that the true impact of sickle RBC membrane defects on clinical phenotype is to add a stochastic influence, thereby modulating (and obscuring the theoretical predictability of) the fundamental predisposition to disease severity conferred by genetic determinants of Hb polymerization is put forth.

TL;DR: It is shown that CD34+ cells and their subsets can be identified in normal PB and that the relative frequency of these Cells and their subpopulations differs in PB versus BM.