Douglas J. Christie

TL;DR: Findings suggest that binding of drug-induced antibodies to platelets occurs at the Fab domains of the IgG molecule.

TL;DR: A 23-year-old woman experienced six distinct episodes of severe combined neutropenia and thrombocytopenia, lymphopenia, and anemia that were due to quinine-dependent antibodies, and that these antibodies recognized epitopes that were different in the three target cell populations.

TL;DR: It is demonstrated that in quinine- and quinidine-induced thrombocytopenia, drug and antibody combine first in the soluble phase to form a complex, which then binds with high affinity to a receptor on the platelet surface (innocent bystander reaction), and that these antibodies are heterogeneous in respect to the amount of drug required to promote their binding to platelets, the number of platelet receptors they recognize, and their binding affinities.

TL;DR: These findings provide the first major evidence for drug-dependent antibodies in association with severe thrombocytopenia and refractoriness to platelet transfusion in alloimmunized leukemia patients and, further, provides the first demonstration of vancomycin- dependent antibodies reactive with platelets.

TL;DR: Findings demonstrate that posttransfusion purpura may be induced by antibodies directed against an alloantigenic epitope, namely HPA-5b (Bra), located on GPIa/IIa, and that clinically significant bleeding can be associated with antibody reactions directed against this GP complex.