D
Douglas L. Rothman
Researcher at Yale University
Publications - 436
Citations - 46876
Douglas L. Rothman is an academic researcher from Yale University. The author has contributed to research in topics: Glycogen & Glutamate receptor. The author has an hindex of 103, co-authored 412 publications receiving 43459 citations. Previous affiliations of Douglas L. Rothman include University of Alberta & Stony Brook University.
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Journal ArticleDOI
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Kitt Falk Petersen,Douglas E. Befroy,Sylvie Dufour,James Dziura,Charlotte E. Ariyan,Douglas L. Rothman,Loretta DiPietro,Gary W. Cline,Gerald I. Shulman +8 more
TL;DR: Elderly study participants were markedly insulin-resistant as compared with young controls, and this resistance was attributable to reduced insulin-stimulated muscle glucose metabolism, which supports the hypothesis that an age-associated decline in mitochondrial function contributes to insulin resistance in the elderly.
Journal ArticleDOI
Mechanism of free fatty acid-induced insulin resistance in humans.
Michael Roden,Thomas B. Price,Gianluca Perseghin,Kitt Falk Petersen,Douglas L. Rothman,Gary W. Cline,Gerald I. Shulman +6 more
TL;DR: It is demonstrated that free fatty acids induce insulin resistance in humans by initial inhibition of glucose transport/phosphorylation which is then followed by an approximately 50% reduction in both the rate of muscle glycogen synthesis and glucose oxidation.
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Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by 13C Nuclear Magnetic Resonance Spectroscopy
Gerald I. Shulman,Douglas L. Rothman,Thomas Jue,Peter J. Stein,Ralph A. DeFronzo,Robert G. Shulman +5 more
TL;DR: It is concluded that muscle glycogen synthesis is the principal pathway of glucose disposal in both normal and diabetic subjects and that defects in muscle glycogens synthesis have a dominant role in the insulin resistance that occurs in persons with NIDDM.
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Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
Alan Dresner,Didier Laurent,Melissa Marcucci,Margaret E. Griffin,Sylvie Dufour,Gary W. Cline,Lori A. Slezak,Dana K. Andersen,Ripudaman S. Hundal,Douglas L. Rothman,Kitt Falk Petersen,Gerald I. Shulman +11 more
TL;DR: Data suggest that increased concentrations of plasma FFA induce insulin resistance in humans through inhibition of glucose transport activity; this may be a consequence of decreased IRS-1-associated PI 3-kinase activity.
Journal ArticleDOI
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.
Martin Krššák,Falk Petersen K,Alan Dresner,Loretta DiPietro,Suzanne M. Vogel,Douglas L. Rothman,Michael Roden,Gerald I. Shulman +7 more
TL;DR: Results show that intramyocellular lipid concentration, as assessed non invasively by localized 1H NMR spectroscopy, is a good indicator of whole body insulin sensitivity in non-diabetic, non-obese humans.