D
Douglas M. Templeton
Researcher at University of Toronto
Publications - 150
Citations - 6530
Douglas M. Templeton is an academic researcher from University of Toronto. The author has contributed to research in topics: Mesangial cell & Cytoskeleton. The author has an hindex of 40, co-authored 149 publications receiving 6165 citations. Previous affiliations of Douglas M. Templeton include Toronto General Hospital.
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Journal ArticleDOI
Guidelines for terms related to chemical speciation and fractionation of elements. Definitions, structural aspects, and methodological approaches (IUPAC Recommendations 2000)
Douglas M. Templeton,Freek Ariese,Rita Cornelis,Lars-Göran Danielsson,Herbert Muntau,Herman P. van Leeuwen,Ryszard Lobinski +6 more
TL;DR: In this paper, the authors defined definitions of concepts related to speciation of elements, more particularly speciation analysis and chemical species, and proposed a categorization of species according to isotopic composition of the element, its oxidation and electronic states, and its complex and molecular structure.
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Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major.
Nancy F. Olivieri,Gary M. Brittenham,Christine E. McLaren,Douglas M. Templeton,Ross G. Cameron,Robert A. McClelland,Alastair D. Burt,Kenneth A. Fleming +7 more
TL;DR: Deferiprone does not adequately control body iron burden in patients with thalassemia and may worsen hepatic fibrosis.
Journal ArticleDOI
Iron-chelation therapy with oral deferiprone in patients with thalassemia major.
Nancy F. Olivieri,Gary M. Brittenham,Doreen Matsui,Matitiahu Berkovitch,Laurence M. Blendis,Ross G. Cameron,Robert A. McClelland,Peter P. Liu,Douglas M. Templeton,Gideon Koren +9 more
TL;DR: Oral deferiprone induces sustained decreases in body iron to concentrations compatible with the avoidance of complications from iron overload, and the risk of agranulocytosis associated with deferrediprone may restrict its administration to patients who are unable or unwilling to use deferoxamine.
Journal ArticleDOI
Multiple roles of cadmium in cell death and survival.
Douglas M. Templeton,Ying Liu +1 more
TL;DR: This review considers the details of apoptotic death, and its inhibition, in renal mesangial cells, and the effect of environmental exposure to cadmium in affecting renal function, and in particular review the evidence for the role of the mesangia cell in cad mium nephrotoxicity.
Journal ArticleDOI
Proteoglycans in cell regulation.
TL;DR: The probable role of proteoglycans in normal glomerular cell function, and in progressive renal disease, will be presented as a harbinger of the significant role they can expect to play in diagnosis and therapy in the near future.