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Drake S. Eggleston
Researcher at GlaxoSmithKline
Publications - 133
Citations - 4236
Drake S. Eggleston is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Crystal structure & Ring (chemistry). The author has an hindex of 28, co-authored 133 publications receiving 3996 citations. Previous affiliations of Drake S. Eggleston include Smith, Kline & French & Laboratory of Molecular Biology.
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Journal ArticleDOI
Histidyl conformations and short N-H...N hydrogen bonds: structure of D,L-histidyl-L,D-histidine pentahydrate.
TL;DR: D,L-Histidyl-L,D-histidine pentahydrate, C12H16-N6O3.5H2O, Mr = 382.38, F(000) = 408, crystallizes in the monoclinic space group Pc with the cell dimensions a = 9.971 (2), b = 4.572 (3) A and beta = 96.08 (1) degree.
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(E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid and related compounds: high affinity leukotriene B4 receptor antagonists.
Robert A. Daines,Chambers Pamela Anne,Drake S. Eggleston,James J. Foley,Don E. Griswold,R. Curtis Haltiwanger,Dalia R. Jakas,William Dennis Kingsbury,Lenox D. Martin +8 more
TL;DR: Compound 11 demonstrated oral LTB4 antagonist activity as well as topical antiinflammatory activity in the mouse and competitively inhibits the binding of [3H]LTB4 to LTB 4 receptors on human polymorphonuclear leukocytes with a Ki of 7.1 nM.
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Synthesis of a 2-benzazepine analog of a potent, nonpeptide GPIIb/IIIa antagonist
TL;DR: In this article, the preparation of the 2-benzazepine derivative 3 as an analog of the potent, nonpeptide GPIIb/IIIa antagonist 2 is reported.
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Molecular structures of l‐Leu‐l‐Tyr, Gly‐d,l‐Met.p‐toluenesulfonate and l‐His‐l‐Leu
TL;DR: Gly-D,L-Met exists as a cation with the N- and C-termini protonated, the p-toluenesulfonate being the counterion, and the leucyl residue is in the g-(tg-) conformation while the tyrosyl residue adopts the g- conformation.
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Synthesis of BRL 55834 - a novel, potent airways-selective potassium channel activator
TL;DR: In this article, an efficient synthesis of the potassium channel activator, BRL 55834, was described and its absolute stereochemistry established as 3S,4R by X-ray crystallographic analysis of the corresponding (S)-α-methylbenzyl carbamate 12.