D
Drake S. Eggleston
Researcher at GlaxoSmithKline
Publications - 133
Citations - 4236
Drake S. Eggleston is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Crystal structure & Ring (chemistry). The author has an hindex of 28, co-authored 133 publications receiving 3996 citations. Previous affiliations of Drake S. Eggleston include Smith, Kline & French & Laboratory of Molecular Biology.
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Journal ArticleDOI
Facile biocatalytic reduction of the carbon–carbon double bond of 5-benzylidenethiazolidine-2,4-diones. Synthesis of (±)-5-(4-{2-[methyl(2-pyridyl)amino]ethoxy}benzyl)thiazolidine-2,4-dione (BRL 49653), its (R)-(+)-enantiomer and analogues
Barrie C. C. Cantello,Drake S. Eggleston,David Haigh,R. Curtis Haltiwanger,Catherine M. Heath,Richard Mark Hindley,Keith R. Jennings,Sime John Thomas,Stefan Roland Woroniecki +8 more
TL;DR: A novel biotransformation system for the reduction of carbon-carbon double bonds in 5-benzylidenethiazolidine-2, 4-diones, using whole cells of red yeasts is described, which are of potential use in the treatment of non-insulin dependent diabetes mellitus.
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ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo
Andy Gribble,Robert J. Ife,Antony Nicholas Shaw,David McNair,C. E. Novelli,S Bakewell,Virendra P. Shah,R. E. Dolle,Pieter H.E. Groot,Neil Pearce,John W. Yates,David G. Tew,H Boyd,S Ashman,Drake S. Eggleston,R C Haltiwanger,G Okafo +16 more
TL;DR: Evidence is provided to support the hypothesis that compounds which inhibit ATP-citrate lyase have the potential to be a novel class of hypolipidemic agent, which possess combined hypocholesterolemic and hypotriglyceridemic activities.
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Guanidyl-carboxylate interactions: crystal structures of arginine dipeptides*
TL;DR: The crystal structures of the hydrated dipeptides larginyl-l-aspartic acid and l-arginyl l-glutamic acid have been determined from three-dimensional X-ray diffraction data as mentioned in this paper.
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Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.
Pamela Brown,Drake S. Eggleston,R. Curtis Haltiwanger,Richard L. Jarvest,Lucy Mensah,Peter J. O'Hanlon,Andrew J. Pope +6 more
TL;DR: Novel inhibitors of bacterial tyrosyl tRNA synthetase have been synthesised in which the cyclic hydroxylamine moiety of SB-219383 is replaced by C-pyranosyl derivatives.
Journal ArticleDOI
Substituent effects on aromatic interactions in the solid state
Harry Adams,Pablo L. Bernad,Drake S. Eggleston,R. Curtis Haltiwanger,Kenneth D. M. Harris,Guy A. Hembury,Christopher A. Hunter,David J. Livingstone,Benson M. Kariuki,James F. McCabe +9 more
TL;DR: A systematic series of structural studies has led to an understanding of how to use hydrogen bonding and steric interactions to control two aromatic rings to interact in a well-defined and predictable manner in the solid state as mentioned in this paper.