The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfactants and/or hydrotropic agents, design of amphiphilic compounds bearing natural or cleavable fragments. Essential advantages of cationic surfactants are the structural diversity of their head groups allowing of chemical modification and introduction of desirable moiety to answer the green chemistry criteria. The latter can be exemplified by the design of novel families of ecological friendly cleavable surfactants, with improved biodegradability, amphiphiles with natural fragments, and geminis with low aggregation threshold. Importantly, the development of amphiphilic nanocarriers for drug delivery allows understanding the correlation between the chemical structure of surfactants, their aggregation behavior, and their functional activity. This review focuses on several aspects related to the synthesis of innovative cationic surfactants and their broad biological applications including antimicrobial activity, solubilization of hydrophobic drugs, complexation with DNA, and catalytic effect toward important biochemical reaction.

/pdf/cationic-surfactants-self-assembly-structure-activity-146jpjjzz3.pdf

Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications.

Self-assembly strategy for the design of soft nanocontainers with controlled properties

Supramolecular systems based on cationic imidazole-containing amphiphiles bearing hydroxyethyl fragment: Aggregation properties and functional activity

Self-assembled systems based on novel hydroxyethylated imidazolium-containing amphiphiles: Interaction with DNA decamer, protein and lipid.

Overcoming skin barriers through advanced transdermal drug delivery approaches.

Cationic liposomes mediated transdermal delivery of meloxicam and ketoprofen: Optimization of the composition, in vitro and in vivo assessment of efficiency.

Self-assembly of the mixed systems based on cationic surfactants and different types of polyanions: The influence of structural and concentration factors

The system based on the cationic surfactant 4-aza-1-hexadecyl-1-azoniabicyclo[2.2.2]-octane bromide (DABCO-16) and the organic electrolyte sodium salicylate was studied by tensiometry, conductometry, pH-metry, dynamic and electrophoretic light scattering, and viscosimetry. The critical concentration of micelle formation of DABCO-16 and the electrokinetic potential decrease sharply and the hydrodynamic diameter of the aggregates increases as the concentration of sodium salicylate increases. The rheological properties of the studied solutions are well described by the Maxwell model for a viscoelastic liquid with one relaxation time. Aqueous solutions DABCO-16—sodium salicylate exhibit the properties of an elastic gel and can be used for the formation of compositions with the improved rheological properties.

Supramolecular system 4-aza-1-hexadecyl-1-azoniabicyclo[2.2.2]octane bromide—sodium salicylate. Aggregation and rheological properties

Методами спектрофотометрии, флуориметрии и динамического рассеяния света исследованы агрегационные и солюбилизирующие свойства систем на основе катионных гидроксиэтилированных геминальных поверхностно-активных веществ (ПАВ) различной гидрофобности и нового амфифильного каликс[4]резорцина с аланиновым остатком по верхнему ободу и н-нонильным заместителем по нижнему ободу по отношению к спектральным зондам (Судан I, куркумин). Определены значения критической концентрации агрегации (ККА) и размеры агрегатов. В случае менее гидрофобного ПАВ исследовано влияние полиакриловой кислоты (ПАК) на агрегационную и солюбилизационную активность. При взаимодействии компонентов наблюдали снижение ККА по сравнению с критической концентрацией мицеллобразования индивидуальной мицеллярной системы. Солюбилизационная активность систем в присутствии ПАК в значительной степени зависит от природы гостя. В случае Судана I происходит усиление солюбилизационных свойств при переходе от индивидуального раствора ПАВ к смешанным системам, а солюбилизация куркумина становится менее эффективной при введении полиэлектролита.

/pdf/supramolecular-nanocontainers-based-on-hydrophobized-calix-4-4ew7sgu5si.pdf

Supramolecular Nanocontainers Based on Hydrophobized Calix[4]resorcinol: Modification by Gemini Surfactants and Polyelectrolyte

/pdf/polymer-colloid-complexes-based-on-a-novel-amphiphilic-3ueutmpem3.pdf

E. A. Vasilieva

Papers

Cationic liposomes mediated transdermal delivery of meloxicam and ketoprofen: Optimization of the composition, in vitro and in vivo assessment of efficiency.

Self-assembly of the mixed systems based on cationic surfactants and different types of polyanions: The influence of structural and concentration factors

Supramolecular system 4-aza-1-hexadecyl-1-azoniabicyclo[2.2.2]octane bromide—sodium salicylate. Aggregation and rheological properties

Supramolecular Nanocontainers Based on Hydrophobized Calix[4]resorcinol: Modification by Gemini Surfactants and Polyelectrolyte

Polymer-Colloid Complexes Based on a Novel Amphiphilic Heterocycle: Aggregation and Solubilization Characteristics