E
E. Ann Hallinan
Researcher at G. D. Searle & Company
Publications - 75
Citations - 866
E. Ann Hallinan is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Oxazepine & Nitric oxide synthase. The author has an hindex of 18, co-authored 75 publications receiving 857 citations. Previous affiliations of E. Ann Hallinan include Metz & Rolf C. Hagen Group.
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Patent
Amidino derivatives useful as nitric oxide synthase inhibitors
Donald W. Hansen,Mark G. Currie,E. Ann Hallinan,Kam F. Fok,Timothy J. Hagen,Arija A. Bergmanis,Steven W. Kramer,Len F. Lee,Suzanne Metz,William M. Moore,Karen B. Peterson,Barnett S. Pitzele,Dale P. Spangler,R. Keith Webber,Mihaly V. Toth,Mahima Trivedi,Foe S. Tjoeng +16 more
TL;DR: The current invention discloses useful pharmaceutical compositions containing amidino derivatives of formula (I) as nitric oxide synthase inhibitors as discussed by the authors, which can be used as a substitute for NOS inhibitors.
Journal ArticleDOI
Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.
E. Ann Hallinan,Sofya Tsymbalov,Clifford R. Dorn,Barnett S. Pitzele,Donald W. Hansen,William M. Moore,Gina M. Jerome,Jane R. Connor,Linda F. Branson,Deborah L. Widomski,Yan Zhang,Mark G. Currie,Pamela T. Manning +12 more
TL;DR: Both the physical properties and the pharmacological profile of 1 make it an ideal molecule for preclinical and clinical studies on the role of selective iNOS inhibitors in mediating inflammatory disease processes.
Journal ArticleDOI
8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic
TL;DR: SC-51322 is the most potent PGE2 antagonist and analgesic that has been seen in this series of N-substituted dibenzoxazepines.
Journal ArticleDOI
2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist.
TL;DR: 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride is a functional PGE2 antagonist selective for the EP1 receptor subtype with antinociceptive activity.
Patent
Amidino compounds useful as nitric oxide synthase inhibitors
Webber Ronald Keith,Durley Richard C,Alok K. Awasthi,Arija A. Bergmanis,Kam F. Fok,Scott S. Ganser,Hagen Timothy J,E. Ann Hallinan,Donald W. Hansen,Brian S. Hickory,Pamela T. Manning,Michael Mao,Alan E. Moormann,Barnett S. Pitzele,Promo Michelle A,Richard R. Schartman,Jeffrey A. Scholten,Jeffrey S. Snyder,Toth Mihaly,Mahima Trivedi,Sofya Tsymbalov,Foe S. Tjoeng +21 more
TL;DR: In this article, a method for making the amidino compounds of formula (I) is described, in which the variables are as defined in the claims, and salts thereof, and a use of the present compounds as nitric oxide synthase inhibitors.