S
Steven W. Kramer
Researcher at G. D. Searle & Company
Publications - 29
Citations - 552
Steven W. Kramer is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Moiety & Azepine. The author has an hindex of 11, co-authored 29 publications receiving 550 citations. Previous affiliations of Steven W. Kramer include Pharmacia.
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Patent
Amidino derivatives useful as nitric oxide synthase inhibitors
Donald W. Hansen,Mark G. Currie,E. Ann Hallinan,Kam F. Fok,Timothy J. Hagen,Arija A. Bergmanis,Steven W. Kramer,Len F. Lee,Suzanne Metz,William M. Moore,Karen B. Peterson,Barnett S. Pitzele,Dale P. Spangler,R. Keith Webber,Mihaly V. Toth,Mahima Trivedi,Foe S. Tjoeng +16 more
TL;DR: The current invention discloses useful pharmaceutical compositions containing amidino derivatives of formula (I) as nitric oxide synthase inhibitors as discussed by the authors, which can be used as a substitute for NOS inhibitors.
Patent
3,4-substituted pyrazoles for the treatment of inflammation
TL;DR: In this article, a class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders, and the compounds of particular interest are defined by formula (II), wherein R1 is selected from alkyl, aralkyl, alkynyl, cyanoalkyl and carboxyalkyl.
Patent
Substituted thiazoles for the treatment of inflammation
John J. Talley,Jeffery S. Carter,Paul W. Collins,Steven W. Kramer,Thomas D. Penning,Donald J. Rogier,Roland S. Rogers +6 more
TL;DR: In this article, a class of substituted thiazolyl compounds is described for use in treating inflammation and inflammation-related disorders, and a formula is defined by Formula (II), wherein R4 is selected from alkyl and amino, and R5 is optionally substituted at a substitutable position with one or more radicals selected from halo.
Journal ArticleDOI
One-pot synthesis of protected prostaglandins from alkynes and cyclopentenones. In situ generation of higher order cyanocuprates derived from alkenylzirconium intermediates
Kevin A. Babiak,James R. Behling,John H. Dygos,Mclaughlin Kathleen T,John S. Ng,Vincent J. Kalish,Steven W. Kramer,Robert L. Shone +7 more
Journal ArticleDOI
4-Fluorinated L-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain
E. Ann Hallinan,Steven W. Kramer,Stephen C. Houdek,William M. Moore,Gina M. Jerome,Dale P. Spangler,Anna M. Stevens,Huey S. Shieh,Pamela T. Manning,Barnett S. Pitzele +9 more
TL;DR: In this paper, the synthesis of 4R-fluoro-L-NIL (12) and 4,4-difluoro-LRL-NLIL (23) was performed as part of the iNOS program.