L
Len F. Lee
Researcher at G. D. Searle & Company
Publications - 14
Citations - 2423
Len F. Lee is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Alkoxy group & Trifluoromethyl. The author has an hindex of 10, co-authored 14 publications receiving 2311 citations.
Papers
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Journal ArticleDOI
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Journal ArticleDOI
Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib).
T. D. Penning,J. J. Tallay,Stephen R. Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro +9 more
Patent
Amidino derivatives useful as nitric oxide synthase inhibitors
Donald W. Hansen,Mark G. Currie,E. Ann Hallinan,Kam F. Fok,Timothy J. Hagen,Arija A. Bergmanis,Steven W. Kramer,Len F. Lee,Suzanne Metz,William M. Moore,Karen B. Peterson,Barnett S. Pitzele,Dale P. Spangler,R. Keith Webber,Mihaly V. Toth,Mahima Trivedi,Foe S. Tjoeng +16 more
TL;DR: The current invention discloses useful pharmaceutical compositions containing amidino derivatives of formula (I) as nitric oxide synthase inhibitors as discussed by the authors, which can be used as a substitute for NOS inhibitors.
Patent
Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
Len F. Lee,Shyamal C. Banerjee,Horng-Chih Huang,Li Jinglin J,Raymond E. Miller,David B. Reitz,Samuel J. Tremont +6 more
TL;DR: In this paper, novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
Patent
Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
Len F. Lee,Shyamal C. Banerjee,Horng-Chih Huang,Li Jinglin J,Raymond E. Miller,David B. Reitz,Samuel J. Tremont +6 more
TL;DR: In this article, novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.