Fundamental Principles Laminar Boundary Layer Flow Laminar Duct Flow External Natural Convection Internal Natural Convection Transition to Turbulence Turbulent Boundary Layer Flow Turbulent Duct Flow Free Turbulent Flows Convection with Change of Phase Mass Transfer Convection in Porous Media.

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Convection Heat Transfer

Microfabricated integrated circuits revolutionized computation by vastly reducing the space, labor, and time required for calculations. Microfluidic systems hold similar promise for the large-scale automation of chemistry and biology, suggesting the possibility of numerous experiments performed rapidly and in parallel, while consuming little reagent. While it is too early to tell whether such a vision will be realized, significant progress has been achieved, and various applications of significant scientific and practical interest have been developed. Here a review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena. Specifically, this review explores the Reynolds number Re, addressing inertial effects; the Peclet number Pe, which concerns convective and diffusive transport; the capillary number Ca expressing the importance of interfacial tension; the Deborah, Weissenberg, and elasticity numbers De, Wi, and El, describing elastic effects due to deformable microstructural elements like polymers; the Grashof and Rayleigh numbers Gr and Ra, describing density-driven flows; and the Knudsen number, describing the importance of noncontinuum molecular effects. Furthermore, the long-range nature of viscous flows and the small device dimensions inherent in microfluidics mean that the influence of boundaries is typically significant. A variety of strategies have been developed to manipulate fluids by exploiting boundary effects; among these are electrokinetic effects, acoustic streaming, and fluid-structure interactions. The goal is to describe the physics behind the rich variety of fluid phenomena occurring on the nanoliter scale using simple scaling arguments, with the hopes of developing an intuitive sense for this occasionally counterintuitive world.

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Microfluidics: Fluid physics at the nanoliter scale

Cell motility in viscous fluids is ubiquitous and affects many biological processes, including reproduction, infection and the marine life ecosystem. Here we review the biophysical and mechanical principles of locomotion at the small scales relevant to cell swimming, tens of micrometers and below. At this scale, inertia is unimportant and the Reynolds number is small. Our emphasis is on the simple physical picture and fundamental flow physics phenomena in this regime. We first give a brief overview of the mechanisms for swimming motility, and of the basic properties of flows at low Reynolds number, paying special attention to aspects most relevant for swimming such as resistance matrices for solid bodies, flow singularities and kinematic requirements for net translation. Then we review classical theoretical work on cell motility, in particular early calculations of swimming kinematics with prescribed stroke and the application of resistive force theory and slender-body theory to flagellar locomotion. After examining the physical means by which flagella are actuated, we outline areas of active research, including hydrodynamic interactions, biological locomotion in complex fluids, the design of small-scale artificial swimmers and the optimization of locomotion strategies. (Some figures in this article are in colour only in the electronic version) This article was invited by Christoph Schmidt.

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The hydrodynamics of swimming microorganisms

A new and very general technique for simulating solid–fluid suspensions is described; its most important feature is that the computational cost scales linearly with the number of particles. The method combines Newtonian dynamics of the solid particles with a discretized Boltzmann equation for the fluid phase; the many-body hydrodynamic interactions are fully accounted for, both in the creeping-flow regime and at higher Reynolds numbers. Brownian motion of the solid particles arises spontaneously from stochastic fluctuations in the fluid stress tensor, rather than from random forces or displacements applied directly to the particles. In this paper, the theoretical foundations of the technique are laid out, illustrated by simple analytical and numerical examples; in a companion paper (Part 2), extensive numerical tests of the method, for stationary flows, time-dependent flows, and finite-Reynolds-number flows, are reported.

Numerical simulations of particulate suspensions via a discretized boltzmann equation: part 1. theoretical foundation

The effect of Brownian motion of particles in a statistically homogeneous suspension is to tend to make uniform the joint probability density functions for the relative positions of particles, in opposition to the tendency of a deforming motion of the suspension to make some particle configurations more common. This smoothing process of Brownian motion can be represented by the action of coupled or interactive steady ‘thermodynamic’ forces on the particles, which have two effects relevant to the bulk stress in the suspension. Firstly, the system of thermodynamic forces on particles makes a direct contribution to the bulk stress; and, secondly, thermodynamic forces change the statistical properties of the relative positions of particles and so affect the bulk stress indirectly. These two effects are analysed for a suspension of rigid spherical particles. In the case of a dilute suspension both the direct and indirect contributions to the bulk stress due to Brownian motion are of order o2, where o([Lt ] 1) is the volume fraction of the particles, and an explicit expression for this leading approximation is constructed in terms of hydrodynamic interactions between pairs of particles. The differential equation representing the effects of the bulk deforming motion and the Brownian motion on the probability density of the separation vector of particle pairs in a dilute suspension is also investigated, and is solved numerically for the case of relatively strong Brownian motion. The suspension has approximately isotropic structure in this case, regardless of the nature of the bulk flow, and the effective viscosity representing the stress system to order ϕ2 is found to be
 \[
 \mu^{*} = \mu(1+2.5\phi + 6.2\phi^2).
 \]
 The value of the coefficient of o2 for steady pure straining motion in the case of weak Brownian motion is known to be 7[sdot ]6, which indicates a small degree of ‘strain thickening’ in the o2-term.

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/72B16FA20D2A14415CDED6A4F042809F/S0022112077001062a.pdf/div-class-title-the-effect-of-brownian-motion-on-the-bulk-stress-in-a-suspension-of-spherical-particles-div.pdf

The effect of Brownian motion on the bulk stress in a suspension of spherical particles

The effect of rotary Brownian motion on the rheology of a dilute suspension of rigid spheroids in shear flow is considered for various limiting cases of the particle aspect ratio r and dimensionless shear rate γ/D. As a preliminary the probability distribution function is calculated for the orientation of a single, axisymmetric particle in steady shear flow, assuming small particle Reynolds number. The result for the case of weak-shear flows, γ/D [Lt ] 1, has been known for many years. After briefly reviewing this limiting case, we present expressions for the case of strong shear where (r3 + r−3) [Lt ] γ/D, and for an intermediate regime relevant for extreme aspect ratios where 1 [Lt ] γ/D [Lt ] (r3 + r−3). The bulk stress is then calculated for these cases, as well as the case of nearly spherical particles r ∼ 1, which has not hitherto been discussed in detail. Various non-Newtonian features of the suspension rheology are discussed in terms of prior continuum mechanical and experimental results.

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The effect of Brownian motion on the rheological properties of a suspension of non-spherical particles

The capillary thinning of a filament of viscoelastic liquid, which is the basis of a microrheometer, is analyzed in terms of a multi-mode FENE fluid. After a short time of viscous adjustment, the stress becomes dominated by the elastic contribution and the strain-rate takes on a value equal to two-thirds the rate at which the stress would relax at fixed strain. This strain-rate decreases as the dominant mode changes. At late times, modes reach their finite extension limit. The fluid then behaves like a suspension of rigid rods with a large extensional viscosity, and the liquid filament breaks. Predictions are compared with the experiments of Liang and Mackley (1994).

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Effect of a spectrum of relaxation times on the capillary thinning of a filament of elastic liquid

The dynamic deformation of a solid elastic sphere which is immersed in a viscous fluid and in close motion toward another sphere or a plane solid surface is presented. The deformed shape of the solid surfaces and the pressure profile in the fluid layer separating these surfaces are determined simultaneously via asymptotic and numerical techniques. This research provides the first steps in establishing rational criteria for predicting whether a solid particle will stick or rebound subsequent to impact during filtration or coagulation when viscous forces are important.

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The elastohydrodynamic collision of two spheres

Approximate constitutive equations are derived for a dilute suspension of rigid spheroidal particles with Brownian rotations, and the behaviour of the approximations is explored in various flows. Following the suggestion made in the general formulation in part 1, the approximations take the form of Hand's (1962) fluid model, in which the anisotropic microstructure is described by a single second-order tensor. Limiting forms of the exact constitutive equations are derived for weak flows and for a class of strong flows. In both limits the microstructure is shown to be entirely described by a second-order tensor. The proposed approximations are simple interpolations between the limiting forms of the exact equations. Predictions from the exact and approximate constitutive equations are compared for a variety of flows, including some which are not in the class of strong flows analysed.

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0022112076003200

Constitutive equations in suspension mechanics. Part 2. Approximate forms for a suspension of rigid particles affected by Brownian rotations

The inertial migration of a small sphere in a Poiseuille flow is calculated for the case when the channel Reynolds number is of order unity. The equilibrium position is found to move towards the wall as the Reynolds number increases. The migration velocity is found to increase more slowly than quadratically. These results are compared with the experiments of Segre & Silberberg (1962 a, b).

http://www.damtp.cam.ac.uk/user/hinch/publications/JFM203_517.pdf

E. J. Hinch

Papers

The effect of Brownian motion on the rheological properties of a suspension of non-spherical particles

Effect of a spectrum of relaxation times on the capillary thinning of a filament of elastic liquid

The elastohydrodynamic collision of two spheres

Constitutive equations in suspension mechanics. Part 2. Approximate forms for a suspension of rigid particles affected by Brownian rotations

Inertial migration of a sphere in Poiseuille flow