E
Edgar Wingender
Researcher at University of Göttingen
Publications - 194
Citations - 19839
Edgar Wingender is an academic researcher from University of Göttingen. The author has contributed to research in topics: TRANSFAC & Promoter. The author has an hindex of 46, co-authored 192 publications receiving 19027 citations. Previous affiliations of Edgar Wingender include Roche Diagnostics.
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Journal Article
Composition-sensitive analysis of the human genome for regulatory signals.
Olga V. Kel-Margoulis,Dmitri Tchekmenev,Alexander E. Kel,Ellen Goessling,Klaus Hornischer,Birgit Lewicki-Potapov,Edgar Wingender +6 more
TL;DR: It is shown that the occurrence of sequence patterns with regulatory potential may be supported by, but cannot be fully explained by either the GC content of a whole chromosome or its putative promoter regions, nor by the information content of the patterns.
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Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer.
Alexander E. Kel,Ulyana A. Boyarskikh,Philip Stegmaier,Leonid S. Leskov,Andrey Sokolov,Ivan S. Yevshin,Nikita Mandrik,Daria Stelmashenko,Jeannette Koschmann,Olga V. Kel-Margoulis,Mathias Krull,Anna Martínez-Cardús,Sebastian Moran,Manel Esteller,Fedor A. Kolpakov,Maxim L. Filipenko,Edgar Wingender +16 more
TL;DR: In this paper, a method for finding potential causal relationships between epigenetic changes (DNA methylations) in gene regulatory regions that affect transcription factor binding sites (TFBS) and gene expression changes was proposed.
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The architecture of the gene regulatory networks of different tissues
TL;DR: A common bow-tie framework was found that underlies the motif instances and shows diverse patterns in different tissues, and could serve as the model to further understand the structural adaptation of the regulatory system to the specific requirements of different cell functions.
Journal Article
Structure of the gene encoding the rat T cell ecto-ADP-ribosyltransferase RT6.
TL;DR: An analysis of the rat RT6 gene is presented, providing a basis for studying the regulation of this gene in T cells of normal and diabetes-prone rats and is the first structural analysis of a mammalian mono-ADP-ribosyltransferase gene.
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The TGF-β–Smad network: introducing bioinformatic tools
TL;DR: The TGF-β–Smad signalling networks and how these processes are represented in databases of signal transduction and transcription control mechanisms can provide a well-structured overview of the subject and a basis for advanced bioinformatics analyses.