E
Edmunds Lukevics
Researcher at Latvian Academy of Sciences
Publications - 350
Citations - 3347
Edmunds Lukevics is an academic researcher from Latvian Academy of Sciences. The author has contributed to research in topics: Catalysis & Crystal structure. The author has an hindex of 25, co-authored 350 publications receiving 3208 citations. Previous affiliations of Edmunds Lukevics include Riga Technical University.
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3-(2,2,2-Trimethylhydrazinium)propionate (THP)--a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties
B Z Simkhovich,Z V Shutenko,Dainuvite Meirena,K B Khagi,R J Mezapuķe,T N Molodchina,I J Kalviņs,Edmunds Lukevics +7 more
TL;DR: The inhibition of fatty acid metabolism at the stage of activation (acyl carnitine formation) can account for the cardioprotective effect of THP, which is assessed by its ability to prevent a decrease in ATP level and myocardial energy charge.
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Design of β-Lactams with Mechanism Based Nonantibacterial Activities
TL;DR: The majority of nonantibacterial activities discovered for β-lactam derivatives during the last 15 years are based on their ability to form a stable covalent complex with nucleophile in the active site of enzymes regulating fundamental physiological processes in mammalian organism such as serine and cysteine proteases, LDL phospholipase A2, A-independent transacylase and some still indeciphered enzymes as discussed by the authors.
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Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.
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Synthesis and antitumour activity of trimethylsilylpropyl substituted benzimidazoles.
Edmunds Lukevics,Pavel Arsenyan,Irina Shestakova,Ilona Domracheva,Alena Nesterova,Olga Pudova +5 more
TL;DR: The insertion of the silicon atom into the N-alkyl chain increases the cytotoxic activity of benzimidazolinium salts significantly, which show a very significant potency in vitro against all studied tumour cell lines, being particularly active in experiments with B16 (mouse melanoma).