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Edoardo Marchesi
Researcher at National Institutes of Health
Publications - 16
Citations - 2042
Edoardo Marchesi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinoic acid receptor alpha & ABL. The author has an hindex of 11, co-authored 15 publications receiving 1996 citations.
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Journal ArticleDOI
Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification.
Philipp le Coutre,Elena Tassi,Marileila Varella-Garcia,Rossella Barni,Luca Mologni,Gonçalo Cabrita,Edoardo Marchesi,Rosanna Supino,Carlo Gambacorti-Passerini +8 more
TL;DR: Overexpression of the Bcr/Abl protein mediated through gene amplification is associated with and probably determines resistance of human leukemic cells to STI571 in vitro.
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In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor
Philipp le Coutre,Luca Mologni,Loredana Cleris,Edoardo Marchesi,Elisabeth Buchdunger,Roberto Giardini,Franca Formelli,Carlo Gambacorti-Passerini +7 more
TL;DR: Evaluated antineoplastic activity of CGP57148B indicates that the continuous block of the oncogenic tyrosine kinase of Bcr/Abl protein is needed to produce important biologic effects in vivo.
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In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells
Miriam Puttini,Addolorata Coluccia,Frank Boschelli,Loredana Cleris,Edoardo Marchesi,Arianna Donella-Deana,Shaheen Ahmed,Sara Redaelli,Rocco Piazza,Vera Magistroni,Federica Andreoni,Leonardo Scapozza,Franca Formelli,Carlo Gambacorti-Passerini +13 more
TL;DR: SKI-606 proved to be an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines and transfectants, with IC(50) values in the low nanomolar range, 1 to 2 logs lower than those obtained with imatinib.
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Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis
Carlo Gambacorti-Passerini,Philipp le Coutre,Luca Mologni,Mirco Fanelli,Carla Bertazzoli,Edoardo Marchesi,Massimo Di Nicola,Andrea Biondi,Gian Marco Corneo,Daniela Belotti,Enrico Pogliani,Nicholas B. Lydon +11 more
TL;DR: The activity of CGP57148B on the spontaneous proliferation of both fresh and cultured, leukemic and normal, BCR/ABL positive and negative cells, and its mechanism of action are investigated to support the use of this molecule in initial clinical studies.
Journal ArticleDOI
Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RARα protein
Said Dermime,Francesco Grignani,Monica Clerici,Clara Nervi,Gabriella Sozzi,Gian Paolo Talamo,Edoardo Marchesi,Franca Formelli,Giorgio Parmiani,Pier Giuseppe Pelicci,Carlo Gambacorti-Passerini +10 more
TL;DR: It is concluded that the occurrence of resistance to ATRA in the NB4.306 cell line is closely associated to the loss of expression of the intact pml/RAR alpha protein.