E
Edward C. Taylor
Researcher at Princeton University
Publications - 518
Citations - 9556
Edward C. Taylor is an academic researcher from Princeton University. The author has contributed to research in topics: Organic synthesis & Thallium. The author has an hindex of 47, co-authored 518 publications receiving 9372 citations. Previous affiliations of Edward C. Taylor include Long Island University & University of Illinois at Urbana–Champaign.
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A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase
Edward C. Taylor,Dietmar G Kuhnt,Chuan Shih,Sharon M. Rinzel,Gerald B. Grindey,Julio C. Barredo,Mehrdad Jannatipour,Richard G. Moran +7 more
TL;DR: L-glutamic acid (15), prepared in five steps from 2-pivaloyl-7-deazaguanine, has been found to be an antitumor agent with its primary site of action at thymidylate synthase rather than purine synthesis.
Journal ArticleDOI
Photochemical reactions of azoxy compounds, nitrones, and aromatic amine N-oxides
Journal ArticleDOI
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
TL;DR: These compounds exhibit significant in vivo activity against L1210 leukemia that is comparable to that observed with methotrexate.
Journal ArticleDOI
Synthesis of pyrazolo 3,4-pyrimidine analogues of the potent agent N-4-2-2-amino-4 3-oxo-7-pyrrolo 2,3-pyrimidin-5-yl ethylbenzoyl-L-glutamic acid (LY231514)
TL;DR: Several pyrazolo[3,4-d ]pyrimidine analogues of the potent antitumor agent N -{4]-2-(2-amino-4(3 H )-oxo-7 H -pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid (LY231514, 5) have been prepared.