Edward E. McKee

TL;DR: It is demonstrated that a general feature of the oxazolidinone class of antibiotics is the inhibition of mammalian mitochondrial protein synthesis, which was similar in mitochondria from all tissues studied.

TL;DR: Neither the extracellular nor total intracellular pool of phenylalanine served as the sole precursor for protein synthesis, and two models of amino acid compartmentation involving aminoacylation of tRNA from both the extacellular and intrace cellular compartments were consistent with the steady state and transient data.

TL;DR: The overall results suggest that tedizolid has less potential to cause myelosuppression and neuropathy than that of linezolid during prolonged treatment courses and may therefore allow for mitochondrial recovery during antibacterial therapy.

TL;DR: An in vitro mitochondrial protein-synthesizing system, which makes use of intact yeast mitochondria, has been developed in order to study mitochondrial gene expression and its control by nuclear-coded proteins and revealed that added adenine and guanine nucleotides increase the overall level of protein synthesis and that the added guanines facilitate polypeptide chain elongation.

TL;DR: AZT is a potent inhibitor of thymidine phosphorylation in heart mitochondria, having an inhibitory concentration (IC)50 of 7.0±0.9 μM, indicating that the toxicity of AZT in some tissues may be mediated by disrupting the substrate supply of TTP for mt-DNA replication.