E
Edward L. Spangler
Researcher at National Institutes of Health
Publications - 79
Citations - 3632
Edward L. Spangler is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T-maze & Morris water navigation task. The author has an hindex of 35, co-authored 79 publications receiving 3445 citations. Previous affiliations of Edward L. Spangler include Community College of Baltimore County & Johns Hopkins Bayview Medical Center.
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Journal ArticleDOI
Dietary restriction benefits learning and motor performance of aged mice.
TL;DR: Age-related declines observed among control groups in tests of motor coordination (rotorod) and learning (complex maze) were prevented by the restriction regime.
Journal ArticleDOI
Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus.
Barbara Shukitt-Hale,Francis C. Lau,Amanda N. Carey,Rachel L. Galli,Edward L. Spangler,Donald K. Ingram,James A. Joseph +6 more
TL;DR: Results indicate that blueberry polyphenols attenuate learning impairments following neurotoxic insult and exert anti-inflammatory actions, perhaps via alteration of gene expression.
Journal ArticleDOI
A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats.
Kara B. Duffy,Edward L. Spangler,Bryan D. Devan,Zhihong Guo,Jonna L. Bowker,Anne M. Janas,Adrienne Hagepanos,Robin K. Minor,Rafael deCabo,Peter R. Mouton,Barbara Shukitt-Hale,James A. Joseph,Donald K. Ingram,Donald K. Ingram +13 more
TL;DR: Blueberry supplementation may protect against neurodegeneration and cognitive impairment mediated by excitotoxicity and oxidative stress and in an in vitro experiment, FaO cells grown in medium supplemented with serum from BB-fed rats had enhanced viability after exposure to hydrogen peroxide.
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Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats.
Robin K. Minor,Daniel L. Smith,Alex M. Sossong,Susmita Kaushik,Suresh Poosala,Edward L. Spangler,George S. Roth,Mark A. Lane,David B. Allison,Rafael de Cabo,Donald K. Ingram,Julie A. Mattison +11 more
TL;DR: It is demonstrated that 2DG increases mortality of male Fischer-344 rats and cardiotoxicity is reconfirmed in a 6-week follow-up study evaluating male Brown Norway rats and a natural form of 2G in addition to again examining effects in Fischer- 344 rats and the original synthetic 1DG.
Journal ArticleDOI
The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster
Chunxu Wang,Chunxu Wang,Charles T. Wheeler,Thomas Alberico,Xiaoping Sun,Jeanne Seeberger,Mara Laslo,Edward L. Spangler,Bradley Kern,Rafael de Cabo,Sige Zou +10 more
TL;DR: The results suggest that the gender-specific prolongevity effect of resveratrol is influenced by dietary composition and resver atrol promotes the survival of flies by modulating genetic pathways that can reduce cellular damage.