E
Edward W. Lowe
Researcher at Vanderbilt University
Publications - 25
Citations - 1766
Edward W. Lowe is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Support vector machine & PubChem. The author has an hindex of 11, co-authored 24 publications receiving 1322 citations. Previous affiliations of Edward W. Lowe include Vanderbilt University Medical Center & Xavier University of Louisiana.
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Proceedings ArticleDOI
Poster: GPU-accelerated artificial neural network for QSAR modeling
TL;DR: A GPU-accelerated OpenCL implementation of a back-propagation artificial neural network for the creation of QSAR models for drug discovery and virtual high-throughput screening, achieving performance equal to that of ∼340 cores.
Proceedings ArticleDOI
Poster: GPU-accelerated rigid body fitting of atomic structures into electron density maps
TL;DR: Three initial fits of 1ubi in a 6.6Å resolution synthesized density map had backbone RMSDs to the correct placement of 2.7, 2.9 and 6.
Journal ArticleDOI
Inactivation of peptidylglycine α-hydroxylating monooxygenase by cinnamic acid analogs.
TL;DR: The data support the reversible formation of a Michael adduct between an active site nucleophile and cinnamate that leads to inactive enzyme, and are of significance given that cinnamates are found in foods, perfumes, cosmetics and pharmaceuticals.
Posted Content
Volume Determination of Globular Proteins by Molecular Dynamics
TL;DR: Molecular dynamics simulations of myoglobin and aspartate aminotransferase, with explicit solvent, are shown to accurately reproduce the experimentally measured molar volumes.