Edwin D. Lephart

TL;DR: It is clear that molecular mechanism(s) account for the diverse expression of aromatase in different neural tissue sites and during various physiological states or developmental periods and further study is necessary in order to understand the significance of the regulation of local estrogen biosynthesis by the arom atase cytochrome P450 gene during prenatal and postnatal development.

TL;DR: Humans have acquired an ability to exclusively synthesize S-equol from the precursor soy isoflavone daidzein, and it is significant that this enantiomer has a relatively high affinity for estrogen receptor beta.

TL;DR: The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment of androgen-mediated pathologies.

TL;DR: The results indicated that consumption of dietary phytoestrogens resulting in very high plasma isoflavone levels over a relatively short period can significantly alter body and prostate weight and plasma androgen hormone levels without affecting gonadotropin or testicular StAR levels.

TL;DR: In this article, the influence of phytoestrogens on brain structure, learning, memory and anxiety along with the brain androgen-metabolizing enzyme, aromatase, was investigated in perinatal, maternal or adult rats.