Effrosyni D. Manali

TL;DR: It is found that the MUC5B promoter variant was associated with rheumatoid arthritis and more specifically associated with evidence of usual interstitial pneumonia on imaging and associated with an increased risk of ILD among patients with RA.

TL;DR: The development of lung complications appears to be associated with older age, duration of treatment and cumulative dosage, high levels of its desethyl metabolite, history of cardiothoracic surgery and/or use of high oxygen mixtures, use of iodinated contrast media and probably pre-existing lung disease as well as co-existing respiratory infections.

TL;DR: Evidence is provided that intermittent sleep oxygen desaturation significantly exceeds that of maximal exercise and is associated with survival in IPF patients, and this work implies the existence of a link between lung damage and apnea events resulting to the induction and severity of intermittent sleep breathing disorders that aggravate pulmonary arterial hypertension and influence IPF survival.

TL;DR: Assessment of pro‐inflammatory and pro‐fibrotic cytokines in the peripheral blood from stable and exacerbated IPF patients found high levels of IL‐6 and IL‐8 characterize early‐on IPF‐AEs and an increase in the levels ofIL‐ 6 andIL‐8 associates with worse outcome in all patients.

TL;DR: CPAP therapy improves QoL and lessens depressive symptoms in the authors' group of well-treated OSA patients, however, physical activity and energy expenditure did not present statistically significant improvement in the same group of Osa patients.