N
Naoyuki Tsuchiya
Researcher at University of Tsukuba
Publications - 195
Citations - 7462
Naoyuki Tsuchiya is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Single-nucleotide polymorphism & Human leukocyte antigen. The author has an hindex of 46, co-authored 191 publications receiving 6824 citations. Previous affiliations of Naoyuki Tsuchiya include Gulf Coast Regional Blood Center & Mitsubishi.
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Journal ArticleDOI
Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus - Contribution of FCGR2B to genetic susceptibility
Chieko Kyogoku,Hilde M. Dijstelbloem,Naoyuki Tsuchiya,Yoko Hatta,Hitoshi Kato,Akihiro Yamaguchi,Toru Fukazawa,Marc D. Jansen,Hiroshi Hashimoto,Jan G. J. van de Winkel,Cees G. M. Kallenberg,Katsushi Tokunaga +11 more
TL;DR: The association of a new polymorphism of FCGR2B (I232T) with susceptibility to SLE in the Japanese demonstrates the possibility that another susceptibility gene of primary significance exists within the FcgammaR region.
Journal ArticleDOI
MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease.
Pierre-Antoine Juge,Joyce S. Lee,Esther Ebstein,Hiroshi Furukawa,Evgenia Dobrinskikh,Steven Gazal,Caroline Kannengiesser,Sébastien Ottaviani,Shomi Oka,Shigeto Tohma,Naoyuki Tsuchiya,Jorge Rojas-Serrano,Montserrat I González-Pérez,Mayra Mejía,Ivette Buendía-Roldán,Ramcés Falfán-Valencia,Enrique Ambrocio-Ortiz,Effrosyni D. Manali,Spyros Papiris,Theofanis Karageorgas,Dimitrios Boumpas,Katarina M. Antoniou,Coline H.M. van Moorsel,Joanne J. van der Vis,Yaël A de Man,Jan C. Grutters,Yaping Wang,Raphael Borie,Lidwine Wemeau-Stervinou,Benoit Wallaert,René-Marc Flipo,Hilario Nunes,Dominique Valeyre,Nathalie Saidenberg-Kermanac’h,Marie-Christophe Boissier,Sylvain Marchand-Adam,Aline Frazier,Pascal Richette,Yannick Allanore,Jean Sibilia,Claire Dromer,Christophe Richez,Thierry Schaeverbeke,Huguette Lioté,Gabriel Thabut,Nadia Nathan,S. Amselem,Martin Soubrier,Vincent Cottin,Annick Clement,Kevin D. Deane,Avram D Walts,Tasha E. Fingerlin,Aryeh Fischer,Jay H. Ryu,Eric L. Matteson,Timothy B Niewold,Deborah Assayag,Andrew J. Gross,Paul J. Wolters,Marvin I. Schwarz,Michael Holers,Joshua J. Solomon,Tracy J. Doyle,Ivan O. Rosas,Cornelis Blauwendraat,Michael A. Nalls,Marie-Pierre Debray,Catherine Boileau,Bruno Crestani,David A. Schwartz,Philippe Dieudé +71 more
TL;DR: It is found that the MUC5B promoter variant was associated with rheumatoid arthritis and more specifically associated with evidence of usual interstitial pneumonia on imaging and associated with an increased risk of ILD among patients with RA.
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Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
Nan Shen,Qiong Fu,Qiong Fu,Yun Deng,Yun Deng,Xiaoxia Qian,Zhao Jian,Kenneth M. Kaufman,Yee Ling Wu,C. Yung Yu,Yuanjia Tang,Ji Yih Chen,Wanling Yang,Maida Wong,Aya Kawasaki,Naoyuki Tsuchiya,Takayuki Sumida,Yasushi Kawaguchi,Hwee Siew Howe,Mo Yin Mok,So Young Bang,Fei Lan Liu,Deh Ming Chang,Yoshinari Takasaki,Hiroshi Hashimoto,John B. Harley,Joel M. Guthridge,Jennifer M. Grossman,Rita M. Cantor,Yeong Wook Song,Sang Cheol Bae,Shunle Chen,Bevra H. Hahn,Yu-Lung Lau,Betty P. Tsao +34 more
TL;DR: A functional polymorphism in type I IFN pathway gene TLR7 predisposing to SLE is established, especially in Chinese and Japanese male subjects, with a stronger effect in male than female subjects.
Journal ArticleDOI
FcγRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling
Hajime Kono,Chieko Kyogoku,Takeshi Suzuki,Naoyuki Tsuchiya,Hiroaki Honda,Kazuhiko Yamamoto,Katsushi Tokunaga,Zen-ichiro Honda +7 more
TL;DR: The present findings indicate that the Ile232Thr substitution affects the localization and function of FcgammaRIIB and that the molecular mechanism may link the polymorphism and susceptibility to SLE.
Journal Article
Effects of galactose depletion from oligosaccharide chains on immunological activities of human IgG.
Naoyuki Tsuchiya,Endo T,Kunio Matsuta,Sadayoshi Yoshinoya,Aikawa T,Kosuge E,Fujio Takeuchi,T Miyamoto,Akira Kobata +8 more
TL;DR: The preparation of galactose depleted IgG (agalacto IgG) and characterized its immunological activities implied the biological function of the carbohydrate moiety of human IgG.