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Ivan O. Rosas
Researcher at Baylor College of Medicine
Publications - 235
Citations - 13627
Ivan O. Rosas is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Idiopathic pulmonary fibrosis & Lung. The author has an hindex of 50, co-authored 193 publications receiving 9072 citations. Previous affiliations of Ivan O. Rosas include Brigham and Women's Hospital & National Institutes of Health.
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Journal ArticleDOI
Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia.
Ivan O. Rosas,Norbert Bräu,Norbert Bräu,Michael F. Waters,Ronaldo C. Go,Bradley D Hunter,Sanjay Bhagani,Daniel Skiest,Mariam Aziz,Nichola Cooper,Ivor S. Douglas,Sinisa Savic,Taryn Youngstein,Lorenzo Del Sorbo,Antonio Cubillo Gracian,David J. De La Zerda,Andrew Ustianowski,Min Bao,Sophie Dimonaco,Emily Graham,Balpreet Matharu,Helen Spotswood,Larry Tsai,Atul Malhotra +23 more
TL;DR: In this paper, a randomized trial involving hospitalized patients with severe Covid-19 pneumonia, the use of tocilizumab did not result in significantly better clinical status or lower mortality than placebo at 28 days.
Journal ArticleDOI
Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent
Mark S. Wilson,Satish K. Madala,Thirumalai R. Ramalingam,Bernadette R. Gochuico,Ivan O. Rosas,Allen W. Cheever,Thomas A. Wynn +6 more
TL;DR: It is demonstrated that fibrosis induced by IL-1β, which mimics BLM-induced fibrosis, is also highly dependent on IL- 17A, illustrating the potential utility of targeting IL-17A in the treatment of drug and inflammation- induced fibrosis.
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Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Fei Liu,David Lagares,Kyoung Moo Choi,Lauren E. Stopfer,Aleksandar Marinkovic,Vladimir Vrbanac,Clemens K. Probst,Samantha E. Hiemer,Thomas H. Sisson,Jeffrey C. Horowitz,Ivan O. Rosas,Laura E. Fredenburgh,Carol Feghali-Bostwick,Xaralabos Varelas,Andrew M. Tager,Daniel J. Tschumperlin,Daniel J. Tschumperlin +16 more
TL;DR: Together, these results identify YAP and TAZ as mechanoactivated coordinators of the matrix-driven feedback loop that amplifies and sustains fibrosis.
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Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis.
Taylor Adams,Jonas C. Schupp,Sergio Poli,Ehab A. Ayaub,Nir Neumark,Farida Ahangari,Sarah G. Chu,Benjamin A. Raby,Benjamin A. Raby,Giuseppe DeIuliis,Michael Januszyk,Qiaonan Duan,Heather A. Arnett,Asim Siddiqui,George R. Washko,Robert J. Homer,Xiting Yan,Ivan O. Rosas,Naftali Kaminski +18 more
TL;DR: A single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, is provided by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 chronic obstructive pulmonary disease (COPD) lungs.
Journal ArticleDOI
MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis
Ivan O. Rosas,Thomas J. Richards,Kazuhisa Konishi,Yingze Zhang,Kevin Gibson,Anna Lokshin,Kathleen O. Lindell,José Cisneros,Sandra D. MacDonald,Annie Pardo,Frank C. Sciurba,James H. Dauber,Moisés Selman,Bernadette R. Gochuico,Naftali Kaminski +14 more
TL;DR: The experiments provide the first evidence for a peripheral blood protein signature in IPF and the two main components, MMP7 and MMP1, are overexpressed in the lung microenvironment and distinguish IPF from other chronic lung diseases.