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Ehsan Mihandoost
Researcher at Islamic Azad University
Publications - 13
Citations - 300
Ehsan Mihandoost is an academic researcher from Islamic Azad University. The author has contributed to research in topics: Melatonin & Free radical scavenger. The author has an hindex of 8, co-authored 13 publications receiving 259 citations. Previous affiliations of Ehsan Mihandoost include Mazandaran University of Medical Sciences & Kashan University of Medical Sciences.
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Journal ArticleDOI
Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis.
Mehran Mohseni,Ehsan Mihandoost,Alireza Shirazi,Zargham Sepehrizadeh,Javad Tavakkoly Bazzaz,Mahmoud Ghazi-Khansari +5 more
TL;DR: It is suggested that melatonin in these doses may provide modulation of bax and bcl-2 expression as well as bax/b cl-2 ratio to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis.
Journal Article
Evaluation of Radio-Protective Effect of Melatonin on Whole Body Irradiation Induced Liver Tissue Damage
TL;DR: It is suggested that administration of melatonin before and after irradiation may reduce liver damage caused by gamma irradiation, and Hepatic MDA levels in irradiated rats that were treated with melatonin were significantly decreased, while GSH levels were significantly increased, when compared to either of the control groups or the melatonin only group.
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Radio-protective effects of melatonin against irradiation-induced oxidative damage in rat peripheral blood
Alireza Shirazi,Alireza Shirazi,Ehsan Mihandoost,Mehran Mohseni,Mahmoud Ghazi-Khansari,Seied Rabie Mahdavi +5 more
TL;DR: Pre-treatment with melatonin (10 mg/kg) is likely to be a threshold concentration for significant protection against lower dose of 2 Gy gamma irradiation compared to higher dose of 8 Gy, therefore it seems that radio-protective effects of melatonin are dose-dependent.
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Can melatonin help us in radiation oncology treatments
TL;DR: Melatonin has been shown to be both a direct free radical scavenger and an indirect antioxidant by stimulating antioxidant enzymes and suppressing prooxidative enzymes activity, and it seems that, in the future, melatonin may improve the therapeutic gain in radiation oncology treatments.
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Consequences of lethal-whole-body gamma radiation and possible ameliorative role of melatonin.
TL;DR: Melatonin pretreatment provides protection against radiation induced mortality, oxidative stress, and immune-suppression, and melatonin appeared to have another radioprotective role, suggesting that melatonin may reduce apoptosis through a caspase-3-mediated pathway by blocking caspasing-3 activity.