Eileen J. Kennedy

TL;DR: This work introduces a new class of fluorescent biosensors that detect biochemical activities in living cells at a resolution up to threefold better than the diffraction limit and suggests that biochemical activities of the cell are spatially organized into an activity architecture whose structural and functional characteristics can be revealed by these new bios Sensors.

TL;DR: The data show that increasing kyn levels results in accelerated skeletal aging by impairing osteoblastic differentiation and increasing osteoclastic resorption, and suggest that kyn could play a role in age‐induced bone loss.

TL;DR: The design of conformationally constrained peptides that disrupt interactions between PKA and AKAPs in an isoform-selective manner are reported, representing a new class of AKAP disruptors to study compartmentalized RII-regulated PKA signaling in cells.

TL;DR: Examination of the effects of the oxidized amino acids di-tyrosine and kynurenine on proliferation, differentiation and Mitogen-Activated Protein Kinase (MAPK) pathway demonstrates that amino acid oxides inhibited BMMSC proliferation, alkaline phosphatase expression and activity and the expression of osteogenic markers.

TL;DR: It is shown that stapled peptides targeting the interface between NCKAP1 and CYFIP1 destabilize the WASF3 complex and suppress RAC1 binding, thereby suppressing invasion.