Meghan E. McGee-Lawrence

TL;DR: Recent advances and discrepancies in how Wnt/Lrp5 signaling regulates osteoblasts and osteocytes are reviewed, new players are introduced, and emerging areas such as the role of Wnt signaling in osteoclastogenesis are discussed.

TL;DR: In this paper, the authors investigated the factors leading to accumulation of intra-and intermuscular fat (myosteatosis) in skeletal muscle and bone and found that increases in intramuscular fat are associated with disuse, altered leptin signaling, sex steroid deficiency, and glucocorticoid treatment, factors that are also implicated in bone marrow adipogenesis.

TL;DR: The expression profiles of a large cohort of epigenetic regulators during osteogenic differentiation of human mesenchymal cells derived from the stromal vascular fraction of adipose tissue (AMSCs) show that the polycomb group protein EZH2 (enhancer of zeste homolog 2) is down-regulated during osteoblastic differentiation of AMSCs, and the epigenetic activity of EZh2 expression declines during terminal osteoblast differentiation and matrix production.

TL;DR: The general properties of Hdacs/Sirts and the research that has revealed their essential functions in bone forming cells and bone resorbing osteoclasts are summarized and the utility of this knowledge for orthopedic applications and bone tissue engineering is offered.

TL;DR: The data show that sclerostin not only alters bone mineralization, but also influences mineral metabolism by altering concentrations of hormones that regulate mineral accretion.