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Ekkehard Gruenig
Researcher at University Hospital Heidelberg
Publications - 31
Citations - 1833
Ekkehard Gruenig is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Pulmonary hypertension & Vascular resistance. The author has an hindex of 19, co-authored 29 publications receiving 1702 citations. Previous affiliations of Ekkehard Gruenig include University of Bologna & Martin Luther University of Halle-Wittenberg.
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Journal ArticleDOI
Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.
Rajiv D. Machado,Micheala A. Aldred,Victoria James,Rachel E. Harrison,Bhakti Patel,Edward C. Schwalbe,Ekkehard Gruenig,Bart Janssen,Rolf Koehler,Werner Seeger,Oliver Eickelberg,Horst Olschewski,C. Gregory Elliott,Eric W. Glissmeyer,John F. Carlquist,Miryoung Kim,Adam Torbicki,Anna Fijałkowska,Grzegorz Szewczyk,Jasmine Parma,Marc Abramowicz,Nazzareno Galiè,Hiroko Morisaki,Shingo Kyotani,Norifumi Nakanishi,Takayuki Morisaki,Marc Humbert,Gérald Simonneau,Olivier Sitbon,Florent Soubrier,Florence Coulet,Nicholas W. Morrell,Richard C. Trembath +32 more
TL;DR: In this paper, the authors present a compilation of data for 144 distinct mutations that alter the coding sequence of the BMPR2 gene identified in 210 independent pulmonary arterial hypertension (PAH) subjects.
Journal ArticleDOI
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia
Rachel E. Harrison,Julia A. Flanagan,Marja Sankelo,S. A. Abdalla,J. Rowell,Rajiv D. Machado,C. G. Elliott,Ivan M. Robbins,Horst Olschewski,Vallerie V. McLaughlin,Ekkehard Gruenig,F. Kermeen,Tarja Laitinen,Nicholas W. Morrell,Richard C. Trembath +14 more
TL;DR: The association of pulmonary arterial hypertension and HHT identifies an important disease complication and appears most common among subjects with defects in ALK-1 receptor signalling, and future studies should focus on detailed molecular analysis of the common cellular pathways disrupted by mutations of ALK1 and BMPR2 that cause inherited pulmonary vascular disease.
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Borderline pulmonary arterial pressure is associated with decreased exercise capacity in scleroderma.
Gabor Kovacs,Robert Maier,Elisabeth Aberer,Marianne Brodmann,Stefan Scheidl,Natascha Tröster,Christian Hesse,Wolfgang Salmhofer,Winfried Graninger,Ekkehard Gruenig,Lewis J. Rubin,Horst Olschewski +11 more
TL;DR: MPAP and resistance in the upper normal range at rest and moderate exercise are associated with decreased exercise capacity and may indicate early pulmonary vasculopathy in patients with systemic sclerosis.
Journal ArticleDOI
Genetic Association of the Serotonin Transporter in Pulmonary Arterial Hypertension
Rajiv D. Machado,Rolf Koehler,Eric W. Glissmeyer,Colin Veal,Jay Suntharalingam,Miryoung Kim,John F. Carlquist,Margaret Town,C. Gregory Elliott,Marius M. Hoeper,Anna Fijałkowska,Marcin Kurzyna,Jennifer R. Thomson,Simon Gibbs,Martin R. Wilkins,Werner Seeger,Nicholas W. Morrell,Ekkehard Gruenig,Richard C. Trembath,Bart Janssen +19 more
TL;DR: Variation of the serotonin transporter gene appears unlikely to confer significant susceptibility to pulmonary arterial hypertension, emphasizing the need for adequately powered cohorts for association analyses to identify not only genetic determinants of disease susceptibility but also inherited modifiers for disease development.
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Adult patients with congenital heart disease and pulmonary arterial hypertension: first open prospective multicenter study of bosentan therapy.
Ingram Schulze-Neick,Nadine Gilbert,Ralf Ewert,Christian Witt,Ekkehard Gruenig,Beate Enke,Mathias M. Borst,Peter Lange,Marius M. Hoeper +8 more
TL;DR: Long-term bosentan treatment in adult patients with PAH-CHD was well tolerated and improved functional status as well as exercise capacity.