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Elaine Radwanski
Researcher at Schering-Plough
Publications - 62
Citations - 1823
Elaine Radwanski is an academic researcher from Schering-Plough. The author has contributed to research in topics: Pharmacokinetics & Cmax. The author has an hindex of 22, co-authored 62 publications receiving 1752 citations. Previous affiliations of Elaine Radwanski include Aster & University of Eastern Finland.
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Journal ArticleDOI
Effect of food on the relative bioavailability of two oral formulations of posaconazole in healthy adults.
TL;DR: The suspension formulation of posaconazole was associated with enhanced systemic exposure and increased relative bioavailability compared with the tablet, and food substantially enhanced the rate and extent of posconazole absorption in healthy subjects.
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Pharmacokinetics of Posaconazole Coadministered with Antacid in Fasting or Nonfasting Healthy Men
TL;DR: The effect of antacid on posaconazole exposure in the fasting or nonfasting state was small and is not considered clinically significant.
Journal ArticleDOI
Pharmacokinetics and Dose Proportionality of Loratadine
James Hilbert,Elaine Radwanski,Ray Weglein,Van Luc,George Perentesis,Samson Symchowicz,Nicola Zampaglione +6 more
TL;DR: The dose proportionality and pharmacokinetics of loratadine, a new nonsedating antihistamine, were studied in normal volunteers and there were no differences in the t1/2β, CL/F, or dose‐adjusted AUC values among the treatments.
Journal ArticleDOI
Clinical, hematologic, and immunologic effects of interleukin-10 in humans.
Amy C. Fuchs,Eric V. Granowitz,Leland Shapiro,Edouard Vannier,Gerhard Lonnemann,Jonathan B. Angel,Jeffrey S. Kennedy,Arthur R. Rabson,Elaine Radwanski,Melton B. Affrime,David L. Cutler,Paul C. Grint,Charles A. Dinarello +12 more
TL;DR: It is concluded that IL-10 administration into humans is without significant side effects, and a single injection reducesex vivo production of IL-6, IL-8, and IFNγ.
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Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive.
Veijo Saano,Veijo Saano,Paul Glue,Paul Glue,Christopher Banfield,Christopher Banfield,Pascale Reidenberg,Pascale Reidenberg,Robert D. Colucci,Robert D. Colucci,Jeffrey W. Meehan,Jeffrey W. Meehan,Pertti Haring,Pertti Haring,Elaine Radwanski,Elaine Radwanski,Amin A. Nomeir,Amin A. Nomeir,Chin-Chung Lin,Chin-Chung Lin,Jensen Peder K,Jensen Peder K,Melton B. Affrime,Melton B. Affrime +23 more
TL;DR: Because of the effect of felbamate on the pharmacokinetics of gestodene and the report of intermenstrual bleeding, it is possible that the contraceptive efficacy of low‐dose combination oral contraceptives may be adversely affected during fel bamate treatment.