L
Leland Shapiro
Researcher at Tufts University
Publications - 13
Citations - 1391
Leland Shapiro is an academic researcher from Tufts University. The author has contributed to research in topics: Cytokine & Proinflammatory cytokine. The author has an hindex of 13, co-authored 13 publications receiving 1335 citations. Previous affiliations of Leland Shapiro include Tufts Medical Center & Hochschule Hannover.
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Journal ArticleDOI
Plasma levels of IL-1β, TNFα and their specific inhibitors in undialyzed chronic renal failure, CAPD and hemodialysis patients
Brian J.G. Pereira,Leland Shapiro,Andrew J. King,Matheos E. Falagas,James A. Strom,Charles A. Dinarello +5 more
TL;DR: The presence of naturally occurring inhibitors of interleukin-1 (IL-1) and tumor necrosis factor (TNF) in a variety of diseases has been demonstrated as discussed by the authors.
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Osmotic regulation of cytokine synthesis in vitro
TL;DR: These studies suggest that IL-1 and osmotic shock utilize the same mitogen-activated protein kinase for signal transduction and IL-8 synthesis.
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Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism
Gilles Kaplanski,Catherine Farnarier,S. Kaplanski,Reuven Porat,Leland Shapiro,Pierre Bongrand,Charles A. Dinarello +6 more
TL;DR: It is concluded that the fixed PBMC IL-8 inducing activity is almost entirely caused by IL-1, that this representsIL-1 alpha bound to a surface lectin or mannose receptor on the monocyte, and that it functions in inflammation via juxtacrine interactions.
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Hyperosmotic Stress as a Stimulant for Proinflammatory Cytokine Production
TL;DR: In PBMC stimulated by hyperosmotic stress, the addition of femtomolar concentrations of bacterial lipopolysaccharide, IL-1, or 1% normal human serum resulted in a synergistic synthesis (at least twice that expected) of IL- 1 alpha,IL-1 beta, TNF-alpha, and IL-8.
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Clinical, hematologic, and immunologic effects of interleukin-10 in humans.
Amy C. Fuchs,Eric V. Granowitz,Leland Shapiro,Edouard Vannier,Gerhard Lonnemann,Jonathan B. Angel,Jeffrey S. Kennedy,Arthur R. Rabson,Elaine Radwanski,Melton B. Affrime,David L. Cutler,Paul C. Grint,Charles A. Dinarello +12 more
TL;DR: It is concluded that IL-10 administration into humans is without significant side effects, and a single injection reducesex vivo production of IL-6, IL-8, and IFNγ.