E
Elaine W. Lamirande
Researcher at National Institutes of Health
Publications - 48
Citations - 4345
Elaine W. Lamirande is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 32, co-authored 47 publications receiving 3873 citations.
Papers
More filters
Journal ArticleDOI
Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity
Ursula J. Buchholz,Alexander Bukreyev,Lijuan Yang,Elaine W. Lamirande,Brian R. Murphy,Kanta Subbarao,Peter L. Collins +6 more
TL;DR: Results identify S among the structural proteins as the only significant SARS-CoV neutralization antigen and protective antigen and show that a single mucosal immunization is highly protective in an experimental animal that supports efficient replication of SARS -CoV.
Journal ArticleDOI
A Severe Acute Respiratory Syndrome Coronavirus That Lacks the E Gene Is Attenuated In Vitro and In Vivo
Marta L. DeDiego,Enrique Alvarez,Fernando Almazán,María Teresa Rejas,Elaine W. Lamirande,Anjeanette Roberts,Wun-Ju Shieh,Sherif R. Zaki,Kanta Subbarao,Luis Enjuanes +9 more
TL;DR: The SARS-CoV that lacks the E gene is attenuated in hamsters, might be a safer research tool, and may be a good candidate for the development of a live attenuated SARS -CoV vaccine.
Journal ArticleDOI
Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS-CoV Infection
Jun Chen,Yuk Fai Lau,Elaine W. Lamirande,Christopher D. Paddock,Jeanine Bartlett,Sherif R. Zaki,Kanta Subbarao +6 more
TL;DR: The cellular immune response to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in 12- to 14-month-old BALB/c mice is characterized, demonstrating the important role of CD4+ but not CD8+ T cells in primary SARS- CoV infection in this model.
Journal ArticleDOI
Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS.
Alexander Bukreyev,Elaine W. Lamirande,Ursula J. Buchholz,Leatrice Vogel,William R. Elkins,Marisa St. Claire,Brian R. Murphy,Kanta Subbarao,Peter L. Collins +8 more
TL;DR: Immunisation of animals with BHPIV3/SARS-S induced the production of SARS-coronavirus-neutralising serum antibodies, indicating that a systemic immune response resulted from mucosal immunisation.
Journal ArticleDOI
Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcγRII-dependent entry into B cells in vitro
Yiu Wing Kam,François Kien,Anjeanette Roberts,Yan Chung Cheung,Elaine W. Lamirande,Leatrice Vogel,Shui Ling Chu,Jane Tse,Jeannette Guarner,Sherif R. Zaki,Kanta Subbarao,Malik Peiris,Béatrice Nal,Ralf Altmeyer +13 more
TL;DR: Results indicate that a recombinant trimeric S protein was able to elicit an efficacious protective immune response in vivo and warrant concern in the safety evaluation of a human vaccine against SARS-CoV.