E
Elan Z. Eisenmesser
Researcher at University of Colorado Denver
Publications - 76
Citations - 4967
Elan Z. Eisenmesser is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Cyclophilin & Active site. The author has an hindex of 26, co-authored 71 publications receiving 4360 citations. Previous affiliations of Elan Z. Eisenmesser include Purdue University & University of Colorado Hospital.
Papers
More filters
Journal ArticleDOI
Intrinsic dynamics of an enzyme underlies catalysis
Elan Z. Eisenmesser,Oscar Millet,Wladimir Labeikovsky,Dmitry M. Korzhnev,Magnus Wolf-Watz,Magnus Wolf-Watz,Daryl A. Bosco,Daryl A. Bosco,Jack J. Skalicky,Jack J. Skalicky,Lewis E. Kay,Dorothee Kern +11 more
TL;DR: It is shown that the intrinsic plasticity of the protein is a key characteristic of catalysis, and the pre-existence of collective dynamics in enzymes before catalysis is a common feature of biocatalysts and that proteins have evolved under synergy pressure between structure and dynamics.
Journal ArticleDOI
Enzyme dynamics during catalysis.
TL;DR: The rates of conformational dynamics of the enzyme strongly correlate with the microscopic rates of substrate turnover, which allow a prediction of the reaction trajectory.
Journal ArticleDOI
Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
Magnus Wolf-Watz,Vu Hong Thai,Katherine A. Henzler-Wildman,Georgia Hadjipavlou,Elan Z. Eisenmesser,Dorothee Kern +5 more
TL;DR: A comparative and quantitative study of activity, structure and dynamics revealed a close link between protein dynamics and catalytic turnover in hyperthermophilic and mesophilic homologs of adenylate kinase.
Journal ArticleDOI
Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases
Tara L. Davis,John R. Walker,Valérie Campagna-Slater,P.J. Finerty,Ragika Paramanathan,Galina Bernstein,Farrell MacKenzie,Wolfram Tempel,Hui Ouyang,Wen Hwa Lee,Wen Hwa Lee,Elan Z. Eisenmesser,Sirano Dhe-Paganon,Sirano Dhe-Paganon +13 more
TL;DR: It is found that regions of the isomerase domain outside the proline-binding surface impart isoform specificity for both in vivo substrates and drug design, and it is hypothesized that there is a well-defined molecular surface corresponding to the substrate-binding S2 position that is a site of diversity in the cyclophilin family.
Journal ArticleDOI
Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A
TL;DR: CypA does not only bind to CAN but also catalyzes efficiently the cis/trans isomerization of the Gly-89–Pro-90 peptide bond, providing experimental evidence for efficient CypA catalysis on a natively folded and biologically relevant protein substrate.