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Elisa Pardella
Researcher at University of Florence
Publications - 10
Citations - 122
Elisa Pardella is an academic researcher from University of Florence. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 5 publications receiving 21 citations.
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Journal ArticleDOI
Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids.
TL;DR: Recent evidence highlighting the key role of amino acid (AA) metabolic reprogramming in cancer cells and the supportive microenvironment in driving resistance to anticancer therapies is provided.
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Role of tyrosine phosphorylation in modulating cancer cell metabolism.
TL;DR: Data reported in this review highlight that tyrosine phosphorylation is not a sporadic event but a widespread post-translational modification, which is essential to promote the metabolic reprogramming of cancer cells.
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Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer.
Luigi Ippolito,Giuseppina Comito,Matteo Parri,Marta Iozzo,Assia Duatti,Francesca Virgilio,Nicla Lorito,Marina Bacci,Elisa Pardella,G. Sandrini,Francesca Bianchini,Roberta Damiano,Lavinia Ferrone,Giancarlo la Marca,Sergio Serni,Pietro Spatafora,Carlo Catalano,Andrea Morandi,Elisa Giannoni,Paola Chiarugi +19 more
TL;DR: Findings show that lactate has both a metabolic and an epigenetic role in promoting PCa progression, and its translational relevance as a therapeutic target in PCa is demonstrated.
Journal ArticleDOI
SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis.
Erica Pranzini,Elisa Pardella,Livio Muccillo,Angela Leo,Ilaria Nesi,Alice Santi,Matteo Parri,Tong Zhang,Alejandro Huerta Uribe,Tiziano Lottini,Lina Sabatino,Anna Caselli,Annarosa Arcangeli,Giovanni Raugei,Vittorio Colantuoni,Paolo Cirri,Paola Chiarugi,Oliver D. K. Maddocks,P Paoli,Maria Letizia Taddei +19 more
TL;DR: In this paper , the serine hydroxymethyltransferase-2 (SHMT2)-driven compartmentalization of one-carbon metabolism inside the mitochondria represents a specific adaptation of resistant cells to support purine biosynthesis and potentiate DNA damage response.
Journal ArticleDOI
Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment.
Elisa Pardella,Erica Pranzini,Angela Leo,Maria Letizia Taddei,Paolo De Paoli,Giovanni Raugei +5 more
TL;DR: It is illustrated how the oncogenic PTPs contributing to melanoma progression could be applied to target both cancer cells and the immune infiltrate of tumors, providing a new promising adjuvant therapy for the treatment of melanoma.