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Elisabeth Becker
Researcher at Ruhr University Bochum
Publications - 2
Citations - 257
Elisabeth Becker is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Peroxisome & Complementation. The author has an hindex of 2, co-authored 2 publications receiving 241 citations.
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Journal ArticleDOI
Human PEX1 is mutated in complementation group 1 of the peroxisome biogenesis disorders
Herma Portsteffen,Andreas Beyer,Elisabeth Becker,Cornelia Epplen,André Pawlak,Wolf-H. Kunau,Gabriele Dodt +6 more
TL;DR: Human PEX1 has been identified by computer-based ‘homology probing’ using the ScPexlp sequence to screen databases of expressed sequence tags (dbEST) for human cDNA clones and expresses a 147-kD member of the AAA protein family (ATPases associated with diverse cellular activities).
Journal ArticleDOI
Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p.
TL;DR: It is proposed that mammalian PEX5L may have acquired some of the functions that yeast Pex18p and/or Pex21p perform in PTS2 protein import, and this hypothesis may explain the essential role of P EX5L in PTS1 protein import in mammalian cells and its lack of importance for PTS2protein import in yeast.