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Elisabeth Ehler
Researcher at King's College London
Publications - 141
Citations - 9282
Elisabeth Ehler is an academic researcher from King's College London. The author has contributed to research in topics: Sarcomere & Myocyte. The author has an hindex of 54, co-authored 132 publications receiving 8503 citations. Previous affiliations of Elisabeth Ehler include University of Cambridge & Randall Division of Cell and Molecular Biophysics.
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Journal ArticleDOI
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.
Peter Carmeliet,Yin-Shan Ng,Dieter Nuyens,Gregor Theilmeier,Koen Brusselmans,Ivo Cornelissen,Elisabeth Ehler,Vijay V. Kakkar,Ingeborg Stalmans,Virginie Mattot,Jean Claude Perriard,Mieke Dewerchin,Willem Flameng,Andras Nagy,Florea Lupu,Lieve Moons,Desire Collen,Patricia A. D'Amore,David T. Shima +18 more
TL;DR: Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms V EGF 164 and VEGF 188 is observed.
Journal ArticleDOI
The Kinase Domain of Titin Controls Muscle Gene Expression and Protein Turnover
Stephan Lange,Fengqing Xiang,Andrey Yakovenko,Anna Vihola,Peter Hackman,Elena Rostkova,Jakob Kristensen,Birgit Brandmeier,Gereon Franzen,Birgitta Hedberg,Lars-Gunnar Gunnarsson,Simon M. Hughes,Sylvie Marchand,Thomas Sejersen,Isabelle Richard,Lars Edström,Elisabeth Ehler,Bjarne Udd,Mathias Gautel +18 more
TL;DR: In this paper, a protein kinase domain (TK) was identified where TK interacts with the zinc-finger protein nbr1 through a mechanically inducible conformation.
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Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
TL;DR: The presence of a calmodulin-binding IQ motif, and a Rho guanine nucleotide exchange factor domain in the COOH-terminal region suggest that obscurin is involved in Ca2+/calmodulin, as well as G protein–coupled signal transduction in the sarcomere.
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Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.
Stephan Lange,Daniel Auerbach,Patricia McLoughlin,Evelyne Perriard,Beat W. Schäfer,Jean-Claude Perriard,Elisabeth Ehler +6 more
TL;DR: It is proposed that DRAL/FHL-2 acts as a specific adaptor protein to couple metabolic enzymes to sites of high energy consumption in the cardiac sarcomere.
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Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα
TL;DR: As PP2A exerts a range of cellular functions including cell cycle regulation and cell fate determination, it was surprised to find that these embryos develop normally until postimplantation, but normal differentiation is significantly impaired.