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Patricia A. D'Amore
Researcher at Massachusetts Eye and Ear Infirmary
Publications - 256
Citations - 36520
Patricia A. D'Amore is an academic researcher from Massachusetts Eye and Ear Infirmary. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 88, co-authored 252 publications receiving 34602 citations. Previous affiliations of Patricia A. D'Amore include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Soluble endoglin contributes to the pathogenesis of preeclampsia.
Shivalingappa Venkatesha,Mourad Toporsian,Chun Lam,Jun-ichi Hanai,Tadanori Mammoto,Yeon Mee Kim,Yeon Mee Kim,Yuval Bdolah,Kee-Hak Lim,Hai Tao Yuan,Towia A. Libermann,Isaac E. Stillman,Drucilla J. Roberts,Patricia A. D'Amore,Franklin H. Epstein,Frank W. Sellke,Roberto Romero,Roberto Romero,Vikas P. Sukhatme,Michelle Letarte,S. Ananth Karumanchi +20 more
TL;DR: A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia.
Journal Article
Oxygen-induced retinopathy in the mouse
Lois E.H. Smith,Eva Wesolowski,Angela McLellan,Sandra K. Kostyk,Robert J. D'Amato,Richard Sullivan,Patricia A. D'Amore +6 more
TL;DR: The authors have described a reproducible and quantifiable mouse model of oxygen-induced retinal neovascularization that should prove useful for the study of pathogenesis and therapeutic intervention for retinal nvascularization in retinopathy of prematurity (ROP) and other vasculopathologies.
Journal ArticleDOI
Blood Vessel Formation: What Is Its Molecular Basis?
TL;DR: It is only when students learn that these vessels with their proper diameters and branches are formed in the embryo, mostly before the heart starts beating, that students begin to appreciate the true complexity of the genetic program that governs the development of the vascular system.
Journal ArticleDOI
Engineering vascularized skeletal muscle tissue.
Shulamit Levenberg,Shulamit Levenberg,Jeroen Rouwkema,Mara L. Macdonald,Evan S. Garfein,Daniel S. Kohane,Diane C. Darland,Robert P. Marini,Clemens van Blitterswijk,Richard C. Mulligan,Patricia A. D'Amore,Robert Langer +11 more
TL;DR: The induction of endothelial vessel networks in engineered skeletal muscle tissue constructs using a three-dimensional multiculture system consisting of myoblasts, embryonic fibroblasts and endothelial cells coseeded on highly porous, biodegradable polymer scaffolds is described.
Journal ArticleDOI
Regulators of angiogenesis.
TL;DR: The goal of this review is to describe those stimulators and inhibitors of angiogenesis that have been best-characterized.