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Elisabeth Perzborn
Researcher at Bayer Corporation
Publications - 236
Citations - 4047
Elisabeth Perzborn is an academic researcher from Bayer Corporation. The author has contributed to research in topics: Alkyl & Alkoxy group. The author has an hindex of 29, co-authored 235 publications receiving 3991 citations. Previous affiliations of Elisabeth Perzborn include Bayer Schering Pharma AG & Bayer.
Papers
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Journal ArticleDOI
NO-independent regulatory site on soluble guanylate cyclase
Johannes-Peter Stasch,Eva Maria Becker,Cristina Alonso-Alija,Heiner Apeler,Klaus Dembowsky,Achim Feurer,Rupert Gerzer,Torsten Minuth,Elisabeth Perzborn,Ulrich Pleiß,Henning Schröder,Werner Schroeder,Elke Stahl,Wolfram Steinke,Alexander Straub,Matthias Schramm +15 more
TL;DR: A pyrazolopyridine is presented that potently stimulates sGC through this site by a mechanism that is independent of NO, which results in antiplatelet activity, a strong decrease in blood pressure and an increase in survival in a low-NO rat model of hypertension, and may offer an approach for treating cardiovascular diseases.
Journal ArticleDOI
NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle
Johannes-Peter Stasch,Peter Schmidt,Cristina Alonso-Alija,Heiner Apeler,Klaus Dembowsky,Michael Haerter,Markus Heil,Torsten Minuth,Elisabeth Perzborn,Ulrich Pleiss,Matthias Schramm,Werner Schroeder,Henning Schröder,Elke Stahl,Wolfram Steinke,Frank Wunder +15 more
TL;DR: A novel type of sGC activator which activates the enzyme even after it has been oxidized by the sGC inhibitor ODQ or rendered haem deficient is identified and may offer a new approach for treating cardiovascular diseases.
Patent
Substituted pyrazole derivatives condensed with six-membered heterocyclic rings
Alexander Straub,Achim Feurer,Alonso-Alija Cristina,Johannes-Peter Stasch,Elisabeth Perzborn,Huetter Joachim,Dembowsky Klaus,Elke Stahl +7 more
TL;DR: In this article, substituted pyrazole derivatives of general formula (I), wherein R?1, R2, R3? and A have the indicated meaning, were described and a method for the production of said derivatives and their use as medicaments was discussed.
Patent
Substituted pyrazole derivatives
Alexander Straub,Achim Feurer,Cristina Alonso-Alija,Elke Stahl,Johannes-Peter Stasch,Elisabeth Perzborn,Hutter Joachim,Dembowsky Klaus +7 more
TL;DR: In this paper, substituted pyrazole derivatives of general formula (I), wherein substituents R?1, R2, R3?, A, X and Y have the indicated meaning, were used for the treatment of cardiovascular diseases.
Patent
Novel dicarboxylic acid derivatives with pharmaceutical properties
Cristina Alonso-Alija,Markus Heil,Dietmar Flubacher,Paul Naab,Johannes-Peter Stasch,Frank Wunder,Klaus Dembowsky,Elisabeth Perzborn,Elke Stahl +8 more
TL;DR: In this paper, the use of compounds of formula (I) and their salts and stereoisomers for producing medicaments used in the treatment of cardiovascular diseases was described, which relates to the use