J
Johannes-Peter Stasch
Researcher at Bayer
Publications - 549
Citations - 17112
Johannes-Peter Stasch is an academic researcher from Bayer. The author has contributed to research in topics: Soluble guanylyl cyclase & Riociguat. The author has an hindex of 65, co-authored 547 publications receiving 15804 citations. Previous affiliations of Johannes-Peter Stasch include Bayer Schering Pharma AG & Wittenberg University.
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Journal ArticleDOI
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
Oleg V. Evgenov,Pal Pacher,Peter Schmidt,György Haskó,Harald H.H.W. Schmidt,Johannes-Peter Stasch +5 more
TL;DR: The discovery, biochemistry, pharmacology and clinical potential of haem-dependent sGC stimulators andHaem-independent sGC activators are reviewed.
Journal ArticleDOI
NO-independent regulatory site on soluble guanylate cyclase
Johannes-Peter Stasch,Eva Maria Becker,Cristina Alonso-Alija,Heiner Apeler,Klaus Dembowsky,Achim Feurer,Rupert Gerzer,Torsten Minuth,Elisabeth Perzborn,Ulrich Pleiß,Henning Schröder,Werner Schroeder,Elke Stahl,Wolfram Steinke,Alexander Straub,Matthias Schramm +15 more
TL;DR: A pyrazolopyridine is presented that potently stimulates sGC through this site by a mechanism that is independent of NO, which results in antiplatelet activity, a strong decrease in blood pressure and an increase in survival in a low-NO rat model of hypertension, and may offer an approach for treating cardiovascular diseases.
Journal ArticleDOI
Soluble Guanylate Cyclase as an Emerging Therapeutic Target in Cardiopulmonary Disease
TL;DR: Soluble guanylate cyclase (sGC), a key enzyme of the nitric oxide (NO) signaling pathway, is attracting rapidly growing interest as a therapeutic target in cardiopulmonary disease, with several sGC agonists currently in clinical development.
Journal ArticleDOI
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
Johannes-Peter Stasch,Peter Schmidt,Pavel I. Nedvetsky,Tatiana Y. Nedvetskaya,H S Arun Kumar,Sabine Meurer,Martin Deile,Ashraf Taye,Andreas Knorr,Harald Lapp,Helmut Müller,Yagmur Turgay,Christiane Rothkegel,Adrian Tersteegen,Barbara K Kemp-Harper,Werner Müller-Esterl,Harald H.H.W. Schmidt +16 more
TL;DR: It is shown in vivo that oxidative stress and related vascular disease states, including human diabetes mellitus, led to an sGC that was indistinguishable from the in vitro oxidized/heme-free enzyme, and BAY 58-2667 was more effective and potentiated under pathophysiological and oxidative stress conditions.
Journal ArticleDOI
Kynurenine is an endothelium-derived relaxing factor produced during inflammation.
Yutang Wang,Hanzhong Liu,Hanzhong Liu,Gavin McKenzie,Paul K. Witting,Johannes-Peter Stasch,Michael Hahn,Dechaboon Changsirivathanathamrong,Ben J. Wu,Ben J. Wu,Helen J. Ball,Shane R. Thomas,Vimal Kapoor,David S. Celermajer,Andrew L. Mellor,John F. Keaney,Nicholas H. Hunt,Roland Stocker,Roland Stocker +18 more
TL;DR: Results identify tryptophan metabolism by Ido as a new pathway contributing to the regulation of vascular tone and the control of blood pressure in spontaneously hypertensive rats.