Elizabeth B. Klerman

TL;DR: The visual subsystem that mediates light-induced suppression of melatonin secretion remains functionally intact in some sightless patients, and constitutes a distinct form of blindness, associated with periodic insomnia, that afflicts most but not all patients with no conscious perception of light.

TL;DR: Consensus-based guidelines are presented for collecting and analyzing melatonin for studies that are conducted in the natural living environment, the clinical setting, and in-patient research facilities under controlled conditions.

TL;DR: Assessment of the intrinsic variability of the different calculations of circadian phase can be applied to allow inference of the statistical significance of phase and phase shift calculations, as well as estimation of sample size or statistical power for the number of subjects within an experimental protocol.

TL;DR: It is shown that irregular sleep and light exposure patterns in college students are associated with delayed circadian rhythms and lower academic performance, and that light-based interventions may be therapeutically effective in improving sleep regularity in this population.

TL;DR: It is hypothesized that under entrained conditions, these age-related changes in the relationship between circadian phase and wake time are likely associated with self-selected light exposure at an earlier circadian phase, which could account for the earlier clock hour to which the endogenous circadian pacemaker is entrained in older people and thereby further increase their propensity to awaken at an even earlier time.