Elizabeth Emslie

TL;DR: It is shown that the intracellular supply of large neutral amino acids in T cells was regulated by pathogens and the T cell antigen receptor (TCR), and that Slc7a5-null T cells were unable to metabolically reprogram in response to antigen and did not undergo clonal expansion or effector differentiation.

TL;DR: It is reported that ICOS signaling inactivates the transcription factor FOXO1, and a Foxo1 genetic deletion allowed for generation of Tfh cells with reduced dependence on ICOS ligand.

TL;DR: A key in vivo role for PKD2 in regulating the function of mature peripheral lymphocytes during adaptive immune responses is revealed and the functional importance of PKC-mediated serine phosphorylation of the PKD catalytic domain forPKD activation and downstream signalling is confirmed.

TL;DR: Mass spectrometry based proteomics identifies SLC7A5 as the predominant amino acid transporter in primary PTEN−/− T-ALL cells and expression of SLC8A5 is critical for the malignant transformation induced by PTEN deletion, revealing the importance of regulated amino acid transport for T-cell malignancies.

TL;DR: In the version of this article initially published, the legend for Figure 7b incorrectly included mutant cells, and this error has been corrected in the HTML and PDF versions of the article.