E
Elizabeth L. Axe
Researcher at Babraham Institute
Publications - 2
Citations - 1712
Elizabeth L. Axe is an academic researcher from Babraham Institute. The author has contributed to research in topics: Endoplasmic reticulum & Autophagosome. The author has an hindex of 2, co-authored 2 publications receiving 1545 citations.
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Journal ArticleDOI
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Elizabeth L. Axe,Simon Walker,Maria Manifava,Priya Chandra,H. Llewelyn Roderick,H. Llewelyn Roderick,Anja Habermann,Gareth Griffiths,Nicholas T. Ktistakis +8 more
TL;DR: It is shown that double FYVE domain–containing protein 1, a PI(3)P-binding protein with unusual localization on ER and Golgi membranes, translocates in response to amino acid starvation to a punctate compartment partially colocalized with autophagosomal proteins, which may be involved in Autophagosome biogenesis.
Journal ArticleDOI
Making autophagosomes: localized synthesis of phosphatidylinositol 3-phosphate holds the clue.
TL;DR: It is concluded that at least some autophagosomes are formed in a starvation-induced, PI3P-enriched membrane compartment dynamically connected to the endoplasmic reticulum (ER) and termed the membranes of this compartment omegasomes (from their omega-like shape).