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Simon Walker

Researcher at Babraham Institute

Publications -  79
Citations -  7450

Simon Walker is an academic researcher from Babraham Institute. The author has contributed to research in topics: Autophagy & Troponin I. The author has an hindex of 34, co-authored 75 publications receiving 5813 citations. Previous affiliations of Simon Walker include Ludwig Maximilian University of Munich & University of Bristol.

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Elizabeth L. Axe, +8 more
- 25 Aug 2008 - 
TL;DR: It is shown that double FYVE domain–containing protein 1, a PI(3)P-binding protein with unusual localization on ER and Golgi membranes, translocates in response to amino acid starvation to a punctate compartment partially colocalized with autophagosomal proteins, which may be involved in Autophagosome biogenesis.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study

Anoop S V Shah, +16 more
- 21 Jan 2015 - 
TL;DR: Although having little effect in men, a high sensitivity troponin assay with sex specific diagnostic thresholds may double the diagnosis of myocardial infarction in women and identify those at high risk of reinfarction and death.
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Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome.

Nicholas L. Mills, +12 more
- 23 Mar 2011 - 
TL;DR: In patients with suspected ACS, implementation of a sensitive troponin assay increased the diagnosis of MI and identified patients at high risk of recurrent MI and death.
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Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

Eleftherios Karanasios, +9 more
- 11 Aug 2016 - 
TL;DR: It is proposed that the nucleation of autophagosomes occurs in regions, where the ULK1 complex coalesces with ER and the ATG9 compartment and its formation requires ER exit and coatomer function.