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Elizabeth L. Mather
Researcher at University of California, Berkeley
Publications - 5
Citations - 710
Elizabeth L. Mather is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Cellular differentiation & Pentamer. The author has an hindex of 5, co-authored 5 publications receiving 688 citations. Previous affiliations of Elizabeth L. Mather include Massachusetts Institute of Technology.
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Journal ArticleDOI
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends.
Frederick W. Alt,Alfred L. M. Bothwell,Michael Knapp,Edward J. Siden,Elizabeth L. Mather,Marian Koshland,David Baltimore +6 more
TL;DR: It was shown that the 3′ ends of the two μ mRNAs do not cross-hybridize, and apparently two separate 3′ terminal sequences for μ mRNA are encoded in the genome, one that specifies an amino acid sequence appropriate for membrane-binding and a second that is involved in secretion.
Journal ArticleDOI
Methylation status and DNase I sensitivity of immunoglobulin genes: changes associated with rearrangement.
TL;DR: The findings indicate that the kappa locus in either germline or rearranged contexts maintains a distinctive DNase I-sensitive, hypomethylated structure in plasmacytomas and hybridomas, irrespective of its level of transcriptional activity.
Journal ArticleDOI
Expression of J chain RNA in cell lines representing different stages of B lymphocyte differentiation
Elizabeth L. Mather,Frederick W. Alt,Alfred L. M. Bothwell,David Baltimore,Marian Elliott Koshland +4 more
TL;DR: During B cell differentiation to pentamer IgM secretion, synthesis of the pentamer joining component, the J chain, is initiated and the encounter of a B cell with antigen or mitogen must trigger events that effect either transcription of J chain sequences or their intranuclear stabilization.
Journal ArticleDOI
Assembly and secretion of pentameric IgM in a fusion between a nonsecreting B cell lymphoma and an IgG-secreting plasmacytoma.
TL;DR: A new immunoglobulin product has been obtained by hybridization of mouse cell lines arrested at different stages in B lymphocyte development, providing further evidence that the induction of B cell differentiation includes a signal for de novo synthesis of the J chain.