Elizabeth M. Deacon

TL;DR: This minireview will focus on the role of protein kinases in apoptosis, which has been implicated both in the upstream induction phase of apoptosis and in the downstream execution stage, as the direct targets for caspases.

TL;DR: It is proposed that PKC-δ is an apoptotic lamin kinase and that efficient lamina disassembly at apoptosis requires both lamin hyperphosphorylation and caspase mediated proteolysis.

TL;DR: It is concluded that spontaneous neutrophil apoptosis involves activation of PKC-δ but is MAP kinase-independent.

TL;DR: The realisation that apoptosis is a fundamental cellular process that impacts the initiation and progression of disease states has led to the broadening of disease model systems under consideration for intervention at the level of the apoptotic programme.

TL;DR: There has been an abundance of literature concerning apoptosis (programmed cell death) and its role in development and disease as discussed by the authors, and many of these studies have focused on investigation of the signal transduction pathways involved in the regulation of cell proliferation and apoptosis.