E
Ella Magal
Researcher at Amgen
Publications - 23
Citations - 1197
Ella Magal is an academic researcher from Amgen. The author has contributed to research in topics: Glial cell line-derived neurotrophic factor & Spiral ganglion. The author has an hindex of 15, co-authored 23 publications receiving 1172 citations.
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Journal ArticleDOI
Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise trauma
Jukka Ylikoski,Ulla Pirvola,Jussi Virkkala,P Suvanto,X.-Q Liang,Ella Magal,Richard A. Altschuler,Josef M. Miller,Mart Saarma +8 more
TL;DR: The results demonstrate that GDNF is likely to be an endogeneous survival factor in the normal mammalian cochlea and it could have application as a pharmacological treatment to prevent secondary auditory nerve degeneration following organ of Corti damage.
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Spiral ganglion neurons are protected from degeneration by GDNF gene therapy.
Masao Yagi,Sho Kanzaki,Kohei Kawamoto,Brian Shin,Pratik P. Shah,Ella Magal,Jackie Sheng,Yehoash Raphael +7 more
TL;DR: Adenoviral-mediated GDNF transgene expression enhanced SGC survival in the left (viral-treated) deafened ears, suggesting that GDNF is one of the survival factors in the inner ear and may help maintain the auditory neurons after insult.
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Hair Cell Protection from Aminoglycoside Ototoxicity by Adenovirus-Mediated Overexpression of Glial Cell Line-Derived Neurotrophic Factor
TL;DR: The results demonstrate the feasibility of gene therapy for cochlear application and suggest that virus-mediated overexpression of GDNF may be developed as a valuable prevention against trauma-induced HC death.
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Rescue and regrowth of sensory nerves following deafferentation by neurotrophic factors.
Richard A. Altschuler,Richard A. Altschuler,Younsook Cho,Younsook Cho,Jukka Ylikoski,Ulla Pirvola,Ella Magal,Josef M. Miller +7 more
TL;DR: Study in the cochlea show that application of exogenous neurotrophic factors can enhance survival of spiral ganglion cells after deafness and induce regrowth of peripheral processes, perhaps by replacing lost endogenous factors.
Journal ArticleDOI
Neuroprotective Effect of Darbepoetin Alfa, a Novel Recombinant Erythropoietic Protein, in Focal Cerebral Ischemia in Rats
Ludmila Belayev,Larissa Khoutorova,Weizhao Zhao,Alexey Vigdorchik,Andrey Belayev,Raul Busto,Ella Magal,Myron D. Ginsberg +7 more
TL;DR: Darbepoetin alfa confers behavioral and histological neuroprotection after focal ischemia in rats and shows improved neuroscores relative to vehicle-treated animals in the 14-day survival period.