Y
Yehoash Raphael
Researcher at University of Michigan
Publications - 188
Citations - 11690
Yehoash Raphael is an academic researcher from University of Michigan. The author has contributed to research in topics: Cochlea & Hair cell. The author has an hindex of 57, co-authored 183 publications receiving 10835 citations. Previous affiliations of Yehoash Raphael include Keio University & New Generation University College.
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Journal ArticleDOI
Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals
Masahiko Izumikawa,Ryosei Minoda,Ryosei Minoda,Kohei Kawamoto,Karen A. Abrashkin,Donald L. Swiderski,David F. Dolan,Douglas E. Brough,Yehoash Raphael +8 more
TL;DR: It is reported that Atoh1, a gene also known as Math1 encoding a basic helix-loop-helix transcription factor and key regulator of hair cell development, induces regeneration of hair cells and substantially improves hearing thresholds in the mature deaf inner ear after delivery to nonsensory cells through adenovectors.
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Surface modification of neural recording electrodes with conducting polymer/biomolecule blends
Xinyan Cui,Valerie A. Lee,Yehoash Raphael,James A. Wiler,Jamille Farraye Hetke,David J. Anderson,David C. Martin +6 more
TL;DR: The results indicate that the chemical composition, morphology, electronic transport, and bioactivity of polymer coatings on electrode surfaces on a multichannel micromachined neural probe can be adjusted by controlling electrochemical deposition conditions.
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Math1 Gene Transfer Generates New Cochlear Hair Cells in Mature Guinea Pigs In Vivo
Kohei Kawamoto,Shin Ichi Ishimoto,Ryosei Minoda,Ryosei Minoda,Douglas E. Brough,Yehoash Raphael +5 more
TL;DR: It is concluded that nonsensory cells in the mature cochlea retain the competence to generate new hair cells after overexpression of Math1 in vivo and that Math1 is necessary and sufficient to direct hair cell differentiation in these mature nonsensary cells.
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Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene
Frank J. Probst,Robert A. Fridell,Yehoash Raphael,Thomas L. Saunders,Aihui Wang,Yong Liang,Robert J. Morell,Jeffrey W. Touchman,Robert H. Lyons,Konrad Noben-Trauth,Thomas B. Friedman,Sally A. Camper +11 more
TL;DR: Shaker-2 mice were found to have an amino acid substitution at a highly conserved position within the motor domain of this myosin this article, which suggests that Myo15 is necessary for actin organization in the hair cells of the cochlea.
Journal ArticleDOI
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
Saskia F. Heeringa,Gil Chernin,Moumita Chaki,Weibin Zhou,Alexis Sloan,Ziming Ji,Letian X. Xie,Leonardo Salviati,Toby W. Hurd,Virginia Vega-Warner,Paul D. Killen,Yehoash Raphael,Shazia Ashraf,Bugsu Ovunc,Dominik S. Schoeb,Heather M. McLaughlin,Rannar Airik,Christopher N. Vlangos,Rasheed Gbadegesin,Bernward Hinkes,Pawaree Saisawat,Eva Trevisson,Mara Doimo,Alberto Casarin,Vanessa Pertegato,Gianpietro Giorgi,Holger Prokisch,Agnès Rötig,Gudrun Nürnberg,Christian Becker,Su Q. Wang,Fatih Ozaltin,Rezan Topaloglu,Aysin Bakkaloglu,Sevcan A. Bakkaloglu,Dominik N. Müller,Antje Beissert,Sevgi Mir,Afig Berdeli,Seza ϖzen,Martin Zenker,Verena Matejas,Carlos Santos-Ocaña,Plácido Navas,Takehiro Kusakabe,Andreas Kispert,Sema Akman,Neveen A. Soliman,Stefanie Krick,Peter Mundel,Jochen Reiser,Peter Nürnberg,Catherine F. Clarke,Roger C. Wiggins,Christian Faul,Friedhelm Hildebrandt +55 more
TL;DR: 6 different mutations in coenzyme Q10 biosynthesis monooxygenase 6 (COQ6) in 13 individuals from 7 families were identified and each mutation was linked to early-onset SRNS with sensorineural deafness, suggesting that coen enzyme Q10-related forms of SRNS and hearing loss can be molecularly identified and potentially treated.