E
Ellen K. Wasan
Researcher at University of Saskatchewan
Publications - 59
Citations - 2601
Ellen K. Wasan is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Liposome & Amphotericin B. The author has an hindex of 22, co-authored 55 publications receiving 2045 citations. Previous affiliations of Ellen K. Wasan include British Columbia Institute of Technology & BC Cancer Agency.
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Journal ArticleDOI
An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery
TL;DR: Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review.
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Biological barriers to cellular delivery of lipid-based DNA carriers.
Marcel B. Bally,Pierrot Harvie,Frances M.P. Wong,Spencer Kong,Ellen K. Wasan,Dorothy L. Reimer +5 more
TL;DR: It is suggested here that a critical element required for efficient transfection is dissociation of lipids bound to the plasmid expression vector following internalization.
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Review and analysis of FDA approved drugs using lipid-based formulations
TL;DR: A review and quantitative analysis of the molecular properties of these approved drugs formulated as lipid systems is provided and starts to build an approach that provides more directed guidance on which type of lipid system is likely to be the best for a particular drug molecule.
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Encapsulation of doxorubicin into thermosensitive liposomes via complexation with the transition metal manganese.
Gigi N.C. Chiu,Sheela A. Abraham,Ludger M. Ickenstein,Rebecca Ng,Göran Karlsson,Katarina Edwards,Ellen K. Wasan,Marcel B. Bally +7 more
TL;DR: The manganese complexation loading method increased the encapsulation efficiency of doxorubicin in thermosensitive liposomes with no major impact on temperature-triggered drug release or pharmacokinetics.
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Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans.
Ellen K. Wasan,Karen H. Bartlett,Pavel Gershkovich,Olena Sivak,Brian Banno,Zhao Wong,Jeffrey Gagnon,Byron D. Gates,Carlos G. Leon,Kishor M. Wasan +9 more
TL;DR: Novel lipid-based AmpB oral formulations were prepared that provide excellent drug solubilization and Antifungal activity was assessed and plasma creatinine determinations as a measure of renal toxicity were assessed.