E
Ellen Wirawan
Researcher at Ghent University
Publications - 10
Citations - 3065
Ellen Wirawan is an academic researcher from Ghent University. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 9, co-authored 10 publications receiving 2723 citations.
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Journal ArticleDOI
Neutrophil extracellular trap cell death requires both autophagy and superoxide generation.
Quinten Remijsen,Tom Vanden Berghe,Ellen Wirawan,Bob Asselbergh,Eef Parthoens,Riet De Rycke,Samuel Noppen,Michel Delforge,Jean Willems,Peter Vandenabeele +9 more
TL;DR: Interestingly, inhibition of either autophagy or NADPH oxidase prevents intracellular chromatin decondensation, which is essential for NETosis and NET formation, and results in cell death characterized by hallmarks of apoptosis, indicating that apoptosis might function as a backup program forNETosis when autophagous activity is prevented.
Journal ArticleDOI
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
Ellen Wirawan,L Vande Walle,Kristof Kersse,Sigrid Cornelis,Sigrid Cornelis,Sofie Claerhout,Isabel Vanoverberghe,Ria Roelandt,R. De Rycke,Jelle Verspurten,Wim Declercq,Patrizia Agostinis,T Vanden Berghe,Saskia Lippens,Peter Vandenabeele +14 more
TL;DR: Findings point to a mechanism by which casp-dependent generation of Beclin-1-C creates an amplifying loop enhancing apoptosis upon growth factor withdrawal.
Journal ArticleDOI
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality
Quinten Remijsen,Taco W. Kuijpers,Ellen Wirawan,Saskia Lippens,Peter Vandenabeele,T Vanden Berghe +5 more
TL;DR: The recent progress made in the identification of the mechanisms involved in NETosis is described and its interplay with autophagy and apoptosis is discussed.
Journal ArticleDOI
Autophagy: for better or for worse
TL;DR: This review gives a comprehensive overview of the autophagic signaling pathway, its role in general cellular processes and its connection to cell death, and a brief summary of the possible contribution of defective autophagy signaling to disease.
Journal ArticleDOI
Major cell death pathways at a glance.
TL;DR: The molecular mechanisms and physiological relevance of four major types of programmed cell death, namely apoptosis, necrosis, autophagic cell death and pyroptosis are discussed.