Elmar Jaeckel

TL;DR: In a retrospective study of patients with AIH, it is found that a rapid response to treatment, based on level of AST after 8 weeks, associates with normalization of transaminase levels in the following year.

TL;DR: In this article, complexed IL-2/anti-IL-2 was used to increase the selectivity of intrahepatic regulatory T cells (Tregs) in the late course of the disease.

TL;DR: It is demonstrated that Tregs of patients with end-stage renal disease (ESRD) are already pre-activated when compared to healthy controls, and even though total CD4+CD25highFOXP3+GARP+ Treg numbers decreased in the first three months after transplantation, frequency of activated T Reg numbers increased significantly, representing up to 40% of all peripheral T Regs.

TL;DR: Kinetics of HCV-specific T-cell responses are heterogeneous in interferon-treated patients with acute hepatitis C, suggesting the decline of T-cells might be a consequence of both apoptosis and homing.

TL;DR: Pediatric and adult AIH seem to be distinct in terms of genetic risk factors and preceding viral infections, and associations cannot prove causal relations, but results suggest that hepatotropic virus infections could be involved in AIH pathogenesis.